Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Onchocerca volvulus | 1.726 | 1 | 1 | |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | esterase, putative | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.726 | 1 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.726 | 1 | 1 |
Mycobacterium ulcerans | lipase LipD | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 0.6999 | 0.4043 | 0.4043 |
Leishmania major | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | microtubule associated protein 2 | 0.0668 | 0.0367 | 0.0367 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.011 | 1 |
Loa Loa (eye worm) | hypothetical protein | 1.726 | 1 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.726 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.726 | 1 | 1 |
Echinococcus multilocularis | sodium bile acid cotransporter | 1.726 | 1 | 1 |
Schistosoma mansoni | sodium-bile acid cotransporter related | 1.726 | 1 | 1 |
Echinococcus multilocularis | microtubule associated protein 2 | 0.0668 | 0.0367 | 0.0367 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0 | 0.5 |
Echinococcus granulosus | sodium bile acid cotransporter | 1.726 | 1 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | beta-lactamase | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0668 | 0.0367 | 0.0367 |
Mycobacterium leprae | conserved hypothetical protein | 0.0035 | 0 | 0.5 |
Schistosoma mansoni | sodium-bile acid cotransporter | 1.0261 | 0.5937 | 0.5937 |
Toxoplasma gondii | ABC1 family protein | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.0035 | 0 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.0035 | 0 | 0.5 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.0035 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.