Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | coagulation factor II (thrombin) | Starlite/ChEMBL | References |
Homo sapiens | coagulation factor X | Starlite/ChEMBL | References |
Homo sapiens | plasminogen activator, urokinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Mastin | plasminogen activator, urokinase | 414 aa | 340 aa | 24.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0057 | 0.5 | 0.5 | |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0057 | 0.5 | 0.5 |
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0057 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.5 | 0.5 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0057 | 0.5 | 0.5 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0057 | 0.5 | 0.5 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0057 | 0.5 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0057 | 0.5 | 0.5 |
Toxoplasma gondii | kringle domain-containing protein | 0.0057 | 0.5 | 0.5 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0057 | 0.5 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0057 | 0.5 | 0.5 |
Brugia malayi | Kringle domain containing protein | 0.0057 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 6.6 uM | Inhibitory activity against thrombin(fIIa) in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 6.6 uM | Inhibitory activity against thrombin(fIIa) in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 7.6 uM | Inhibitory activity against Coagulation factor X in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 7.6 uM | Inhibitory activity against Coagulation factor X in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 8.6 uM | Inhibitory activity against urokinase-type plasminogen activator (microPa) in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 8.6 uM | Inhibitory activity against urokinase-type plasminogen activator (microPa) in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 32 uM | Inhibitory activity against plasmin in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 32 uM | Inhibitory activity against plasmin in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 42 uM | Inhibitory activity against trypsin in human plasma | ChEMBL. | 11459634 |
Ki (binding) | = 42 uM | Inhibitory activity against trypsin in human plasma | ChEMBL. | 11459634 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.