Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0403 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.5 | 0.5 |
Brugia malayi | Carboxylesterase family protein | 0.0403 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0403 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0403 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0403 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0403 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0403 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0403 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0403 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0403 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0403 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 40 % | In vitro inhibitory activity of the compound against 5-lipoxygenase was determined at 16 microM | ChEMBL. | No reference |
Inhibition (binding) | < 40 % | In vitro inhibitory activity of the compound against Cyclooxygenase was determined at 16 microM | ChEMBL. | No reference |
Inhibition (binding) | < 40 % | Inhibition of LTB4 in whole cell 5-lipoxygenase assay in an intact rat basophilic leukemia (RBL-1) cell line | ChEMBL. | 8515419 |
Inhibition (binding) | < 40 % | Inhibition of PGF2-alpha formation in Prostaglandin G/H synthase assay in an intact rat basophilic leukemia (RBL-1) cell line at 16 microM | ChEMBL. | 8515419 |
Inhibition (binding) | < 40 % | In vitro inhibitory activity of the compound against 5-lipoxygenase was determined at 16 microM | ChEMBL. | No reference |
Inhibition (binding) | < 40 % | In vitro inhibitory activity of the compound against Cyclooxygenase was determined at 16 microM | ChEMBL. | No reference |
Inhibition (binding) | < 40 % | Inhibition of LTB4 in whole cell 5-lipoxygenase assay in an intact rat basophilic leukemia (RBL-1) cell line | ChEMBL. | 8515419 |
Inhibition (binding) | < 40 % | Inhibition of PGF2-alpha formation in Prostaglandin G/H synthase assay in an intact rat basophilic leukemia (RBL-1) cell line at 16 microM | ChEMBL. | 8515419 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.