TDR Targets

Basic information

Technical information

TDR Targets ID: 767002
Name: 6-[(4-bromophenyl)methylidene]-3-(3,4,5-trime thoxyphenyl)-[1,3]thiazolo[3,2-d][1,2,4]triaz ol-5-one
MW: 478.36 | Formula: C20H20BrN3O4S
H donors: 0 H acceptors: 3 LogP: 4.35 Rotable bonds: 5
Rule of 5 violations (Lipinski): 1
SMILES: COc1cc(cc(c1OC)OC)C1NNC2N1C(=O)C(=Cc1ccc(cc1)Br)S2
InChi: 1S/C20H16BrN3O4S/c1-26-14-9-12(10-15(27-2)17(14)28-3)18-22-23-20-24(18)19(25)16(29-20)8-11-4-6-13(21)7-5-11/h4-10H,1-3H3/b16-8-
InChiKey: AUYXPNPYVMJKNS-PXNMLYILSA-N

Network

Hover on a compound node to display the structore

Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

This is a work in progress. Come back soon to try this features!

Clustering layers

This is a work in progress. Come back soon to try this features!

Synonyms

6-[(4-bromophenyl)methylene]-3-(3,4,5-trimethoxyphenyl)thiazolo[3,2-d][1,2,4]triazol-5-one
6-[(4-bromophenyl)methylene]-3-(3,4,5-trimethoxyphenyl)-5-thiazolo[3,2-d][1,2,4]triazolone
6-(4-bromobenzylidene)-3-(3,4,5-trimethoxyphenyl)thiazolo[3,2-d][1,2,4]triazol-5-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology

No druggable targets predicted by orthology data

By sequence similarity to non orthologous known druggable targets

No druggable targets predicted by sequence similarity

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	transient receptor potential channel	0.0191	1	1
Echinococcus granulosus	thioredoxin glutathione reductase	0.004	0.0497	0.0497
Trypanosoma cruzi	trypanothione reductase, putative	0.004	0.0464	0.5
Echinococcus granulosus	transient receptor potential ion channel A	0.0185	0.9598	0.9598
Brugia malayi	glutathione reductase	0.004	0.0464	0.105
Loa Loa (eye worm)	hypothetical protein	0.007	0.2372	0.2372
Mycobacterium tuberculosis	Probable oxidoreductase	0.0101	0.4316	1
Loa Loa (eye worm)	thioredoxin reductase	0.004	0.0464	0.0464
Schistosoma mansoni	hypothetical protein	0.0038	0.0341	0.0341
Echinococcus granulosus	short transient receptor potential channel 6	0.0126	0.5922	0.5922
Brugia malayi	hypothetical protein	0.0038	0.0341	0.0772
Plasmodium falciparum	glutathione reductase	0.004	0.0464	0.5
Mycobacterium tuberculosis	Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB	0.0091	0.3677	0.8342
Schistosoma mansoni	transient receptor potential channel	0.0126	0.5922	0.5922
Entamoeba histolytica	hypothetical protein	0.0038	0.0341	0.5
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1063	0.1063
Entamoeba histolytica	hypothetical protein	0.0038	0.0341	0.5
Plasmodium falciparum	thioredoxin reductase	0.004	0.0464	0.5
Loa Loa (eye worm)	hypothetical protein	0.0071	0.2435	0.2435
Brugia malayi	latrophilin 2 splice variant baaae	0.007	0.2372	0.5371
Mycobacterium leprae	DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE	0.0101	0.4316	1
Schistosoma mansoni	transient receptor potential channel 4	0.0191	1	1
Mycobacterium tuberculosis	NAD(P)H quinone reductase LpdA	0.0101	0.4316	1
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0102	0.4417	0.4417
Echinococcus multilocularis	short transient receptor potential channel 6	0.0126	0.5922	0.5922
Loa Loa (eye worm)	glutathione reductase	0.004	0.0464	0.0464
Schistosoma mansoni	transcription factor LCR-F1	0.0038	0.0341	0.0341
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1063	0.1063
Echinococcus granulosus	short transient receptor potential channel 6	0.0126	0.5922	0.5922
Echinococcus multilocularis	thioredoxin glutathione reductase	0.004	0.0497	0.0497
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1063	0.1063
Schistosoma mansoni	hypothetical protein	0.0166	0.8405	0.8405
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	0.0049	0.1063	0.2408
Mycobacterium tuberculosis	Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras	0.0101	0.4316	1
Plasmodium vivax	glutathione reductase, putative	0.004	0.0464	0.5
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0102	0.4417	1
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0102	0.4417	1
Brugia malayi	Transient-receptor-potential like protein	0.0071	0.2435	0.5513
Schistosoma mansoni	hypothetical protein	0.0166	0.8405	0.8405
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	0.0049	0.1063	0.1063
Entamoeba histolytica	hypothetical protein	0.0038	0.0341	0.5
Echinococcus multilocularis	short transient receptor potential channel 6	0.0126	0.5922	0.5922
Toxoplasma gondii	thioredoxin reductase	0.004	0.0464	0.5
Mycobacterium tuberculosis	Probable membrane NADH dehydrogenase NdhA	0.0091	0.3677	0.8342
Loa Loa (eye worm)	hypothetical protein	0.0102	0.4417	0.4417
Brugia malayi	Thioredoxin reductase	0.004	0.0464	0.105
Mycobacterium tuberculosis	Probable NADH dehydrogenase Ndh	0.0091	0.3677	0.8342
Echinococcus multilocularis	geminin	0.0166	0.8405	0.8405
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1063	0.1063
Trypanosoma brucei	trypanothione reductase	0.004	0.0464	0.5
Echinococcus granulosus	geminin	0.0166	0.8405	0.8405
Mycobacterium tuberculosis	Putative ferredoxin reductase	0.0091	0.3677	0.8342
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0038	0.0341	0.0341
Entamoeba histolytica	hypothetical protein	0.0038	0.0341	0.5
Mycobacterium tuberculosis	Probable reductase	0.0091	0.3677	0.8342
Echinococcus multilocularis	transient receptor potential gamma protein	0.0191	1	1
Schistosoma mansoni	transient receptor potential channel	0.0126	0.5922	0.5922
Echinococcus multilocularis	transient receptor potential ion channel A	0.0185	0.9598	0.9598
Plasmodium vivax	thioredoxin reductase, putative	0.004	0.0464	0.5
Loa Loa (eye worm)	hypothetical protein	0.0065	0.2034	0.2034
Echinococcus granulosus	TRP transient receptor potential channel	0.0071	0.2435	0.2435
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0049	0.1063	0.1063
Echinococcus multilocularis	TRP (transient receptor potential) channel	0.0071	0.2435	0.2435
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	0.0049	0.1063	0.1063
Loa Loa (eye worm)	hypothetical protein	0.012	0.5521	0.5521
Leishmania major	trypanothione reductase	0.004	0.0464	0.5
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	0.0049	0.1063	0.1063
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0038	0.0341	0.0341
Mycobacterium tuberculosis	Probable dehydrogenase	0.0091	0.3677	0.8342
Loa Loa (eye worm)	hypothetical protein	0.0191	1	1
Schistosoma mansoni	hypothetical protein	0.007	0.2372	0.2372

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Search by Saint Jude

Bibliographic References

No literature references available for this target.

If you have references for this compound, please enter them in a user comment (below) or Contact us.

Detailed information for compound 767002