Detailed information for compound 767198

Basic information

Technical information
  • TDR Targets ID: 767198
  • Name: 6-[[1-(4-butan-2-ylphenyl)-2,5-dimethylpyrrol -3-yl]methylidene]-5-imino-[1,3]thiazolo[3,2- a]pyrimidin-7-one
  • MW: 404.528 | Formula: C23H24N4OS
  • H donors: 0 H acceptors: 1 LogP: 5.07 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(c1ccc(cc1)n1c(C)cc(c1C)C=C1C(=O)N=c2n(C1=N)ccs2)C
  • InChi: 1S/C23H24N4OS/c1-5-14(2)17-6-8-19(9-7-17)27-15(3)12-18(16(27)4)13-20-21(24)26-10-11-29-23(26)25-22(20)28/h6-14,24H,5H2,1-4H3/b20-13-,24-21?
  • InChiKey: RPRUOEQNNOUZFB-VAPLQANRSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 6-[[2,5-dimethyl-1-(4-sec-butylphenyl)pyrrol-3-yl]methylene]-5-imino-thiazolo[3,2-a]pyrimidin-7-one
  • 6-[[2,5-dimethyl-1-(4-sec-butylphenyl)-3-pyrrolyl]methylene]-5-imino-7-thiazolo[3,2-a]pyrimidinone
  • 6-[[1-(4-butan-2-ylphenyl)-2,5-dimethyl-pyrrol-3-yl]methylidene]-5-imino-[1,3]thiazolo[3,2-a]pyrimidin-7-one

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0059 0.0266 0.0266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5733 0.5
Echinococcus multilocularis sodium bile acid cotransporter 0.0476 1 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0363 0.0363
Brugia malayi jmjC domain containing protein 0.0059 0.0266 0.0266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5733 0.5
Echinococcus granulosus lysine specific demethylase 5A 0.0059 0.0266 0.0266
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0266 0.0266
Schistosoma mansoni jumonji domain containing protein 0.0059 0.0266 0.0266
Echinococcus multilocularis lysine specific demethylase 5A 0.0059 0.0266 0.0266
Brugia malayi jmjC domain containing protein 0.0059 0.0266 0.0266
Echinococcus multilocularis sodium bile acid cotransporter 0.0476 1 1
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0363 0.0363
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0363 0.0363
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5733 0.5
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0363 0.0363
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0363 0.0363
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0266 0.0266
Echinococcus multilocularis sodium bile acid cotransporter 0.0476 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5733 0.5
Echinococcus granulosus sodium bile acid cotransporter 0.0476 1 1
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0363 0.0363
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5733 0.5
Loa Loa (eye worm) RNA binding protein 0.0063 0.0363 0.0363
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5733 0.5
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0363 0.0363
Schistosoma mansoni sodium-bile acid cotransporter 0.0283 0.5495 0.5495
Brugia malayi RNA binding protein 0.0063 0.0363 0.0363
Schistosoma mansoni sodium-bile acid cotransporter related 0.0193 0.3395 0.3395
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.5733 0.5
Echinococcus granulosus sodium bile acid cotransporter 0.0476 1 1
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0293 0.5733 0.5
Treponema pallidum fructose-bisphosphate aldolase 0.0293 0.5733 0.5
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0363 0.0363
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0059 0.0266 0.0266
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0143 0.2232 0.5
Echinococcus granulosus tar DNA binding protein 0.0063 0.0363 0.0363
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0143 0.2232 0.5
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5733 0.5
Schistosoma mansoni jumonji/arid domain-containing protein 0.0059 0.0266 0.0266
Giardia lamblia Fructose-bisphosphate aldolase 0.0293 0.5733 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0363 0.0363
Onchocerca volvulus 0.0476 1 0.5
Loa Loa (eye worm) hypothetical protein 0.0476 1 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0293 0.5733 0.5
Brugia malayi TAR-binding protein 0.0063 0.0363 0.0363
Schistosoma mansoni sodium-bile acid cotransporter related 0.0476 1 1
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0143 0.2232 0.5
Echinococcus granulosus sodium bile acid cotransporter 0.0476 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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