Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0128 | 1 | 1 |
Echinococcus granulosus | prolyl endopeptidase | 0.0128 | 1 | 0.5 |
Trypanosoma brucei | prolyl endopeptidase | 0.0128 | 1 | 1 |
Echinococcus multilocularis | prolyl endopeptidase | 0.0128 | 1 | 0.5 |
Mycobacterium ulcerans | protease II (oligopeptidase B), PtrB | 0.0051 | 0.1483 | 0.5 |
Trypanosoma cruzi | prolyl endopeptidase | 0.0128 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0055 | 0.1916 | 0.1916 |
Leishmania major | prolyl oligopeptidase, putative,serine peptidase clan SC, family S9A, putative | 0.0128 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0055 | 0.1916 | 0.1916 |
Mycobacterium tuberculosis | Probable protease II PtrBa [first part] (oligopeptidase B) | 0.0115 | 0.8517 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0055 | 0.1916 | 0.1916 |
Toxoplasma gondii | prolyl endopeptidase | 0.0128 | 1 | 0.5 |
Mycobacterium leprae | PROBABLE PROTEASE II PTRBB (OLIGOPEPTIDASE B) | 0.0051 | 0.1483 | 0.5 |
Schistosoma mansoni | prolyl oligopeptidase (S09 family) | 0.0128 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0055 | 0.1916 | 0.1916 |
Onchocerca volvulus | Prolyl endopeptidase homolog | 0.0128 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.