Detailed information for compound 771530

Basic information

Technical information
  • TDR Targets ID: 771530
  • Name: 4-(6,7,8,9-tetrahydrodibenzofuran-2-ylsulfamo yl)benzoic acid
  • MW: 371.407 | Formula: C19H17NO5S
  • H donors: 2 H acceptors: 4 LogP: 3.6 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: OC(=O)c1ccc(cc1)S(=O)(=O)Nc1ccc2c(c1)c1CCCCc1o2
  • InChi: 1S/C19H17NO5S/c21-19(22)12-5-8-14(9-6-12)26(23,24)20-13-7-10-18-16(11-13)15-3-1-2-4-17(15)25-18/h5-11,20H,1-4H2,(H,21,22)
  • InChiKey: QQKZCDBXQBYWGO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • ChemDiv2_005269

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis DNA polymerase delta catalytic subunit 0.0042 1 1
Schistosoma mansoni DNA polymerase epsilon catalytic subunit 0.0014 0.094 0.094
Echinococcus granulosus DNA polymerase zeta catalytic subunit 0.0014 0.094 0.094
Loa Loa (eye worm) hypothetical protein 0.0014 0.094 0.094
Schistosoma mansoni DNA polymerase alpha catalytic subunit 0.0014 0.094 0.094
Onchocerca volvulus DNA polymerase alpha catalytic subunit homolog 0.0014 0.094 0.094
Plasmodium falciparum DNA polymerase delta catalytic subunit 0.0042 1 0.5
Toxoplasma gondii DNA polymerase 0.0042 1 1
Leishmania major DNA polymerase delta catalytic subunit, putative 0.0042 1 1
Trypanosoma brucei DNA polymerase delta catalytic subunit, putative 0.0042 1 1
Schistosoma mansoni DNA polymerase zeta catalytic subunit 0.0014 0.094 0.094
Brugia malayi DNA polymerase family B, exonuclease domain containing protein 0.0014 0.094 0.094
Onchocerca volvulus DNA polymerase homolog 0.0014 0.094 0.094
Echinococcus multilocularis DNA polymerase zeta catalytic subunit 0.0014 0.094 0.094
Trichomonas vaginalis DNA polymerase zeta catalytic subunit, putative 0.0042 1 1
Echinococcus granulosus DNA polymerase alpha catalytic subunit 0.0014 0.094 0.094
Entamoeba histolytica DNA polymerase delta catalytic subunit, putative 0.0042 1 0.5
Echinococcus multilocularis dna polymerase epsilon catalytic subunit a 0.0014 0.094 0.094
Echinococcus multilocularis DNA polymerase alpha catalytic subunit 0.0014 0.094 0.094
Brugia malayi DNA polymerase alpha catalytic subunit 0.0014 0.094 0.094
Plasmodium vivax DNA polymerase delta catalytic subunit, putative 0.0042 1 1
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0042 1 1
Echinococcus granulosus dna polymerase epsilon catalytic subunit a 0.0014 0.094 0.094
Schistosoma mansoni DNA polymerase delta catalytic subunit 0.0042 1 1
Trypanosoma cruzi DNA polymerase delta catalytic subunit, putative 0.0034 0.7523 0.7266
Brugia malayi DNA polymerase family B containing protein 0.0014 0.094 0.094
Echinococcus granulosus DNA polymerase delta catalytic subunit 0.0042 1 1
Onchocerca volvulus DNA polymerase delta catalytic subunit homolog 0.0042 1 1
Onchocerca volvulus DNA polymerase epsilon catalytic subunit A homolog 0.0014 0.094 0.094
Loa Loa (eye worm) DNA-directed DNA polymerase III 0.0042 1 1
Giardia lamblia DNA polymerase delta, catalytic subunit 0.0042 1 1

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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