Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | glutamate receptor NMDA | 0.0087 | 0.3289 | 0.3289 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0111 | 0.6138 | 0.5 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0095 | 0.4255 | 0.1439 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0145 | 1 | 1 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0095 | 0.4255 | 0.4255 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
ED50 (functional) | = 35.5 mg kg-1 | Inhibition of locomotor activity (LMA) and motor coordination in mice by intraperitoneal administration. | ChEMBL. | 2888897 |
ED50 (functional) | > 100 mg kg-1 | Inhibition of ataxia in mice by intraperitoneal administration. | ChEMBL. | 2888897 |
IC50 (binding) | > 1000 nM | In vitro binding affinity against Dopamine receptor D2 by displacement of [3H]-haloperidol from rat striatal membranes. | ChEMBL. | 2888897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.