Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0147 | 0.3569 | 0.3569 |
Brugia malayi | Voltage-gated potassium channel, KCNQ (Kv7-like) alpha-subunit. C. elegans kqt-1 ortholog | 0.0147 | 0.3569 | 1 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0147 | 0.3569 | 0.2865 |
Schistosoma mansoni | hypothetical protein | 0.0348 | 1 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0052 | 0.0521 | 0.1459 |
Loa Loa (eye worm) | potassium voltage-gated channel subfamily Q member 5 | 0.0066 | 0.0987 | 0.2828 |
Echinococcus multilocularis | geminin | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0052 | 0.0521 | 0.1492 |
Schistosoma mansoni | hypothetical protein | 0.0348 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0052 | 0.0521 | 0.1492 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0147 | 0.3569 | 0.2865 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0987 | 0.2828 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0987 | 0.2828 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0052 | 0.0521 | 0.1459 |
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0144 | 0.349 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.