Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | epidermal growth factor receptor | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Chlamydia trachomatis | 4-hydroxy-tetrahydrodipicolinate synthase | 0.0113 | 0.0262 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0187 | 0.32 |
Toxoplasma gondii | dihydrodipicolinate synthase | 0.0113 | 0.0262 | 0.5 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0097 | 0.0187 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0097 | 0.0187 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0182 | 0.3117 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0058 | 0.0008 | 0.0145 |
Mycobacterium ulcerans | malate synthase G | 0.2253 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrodipicolinate synthase | 0.0113 | 0.0262 | 0.5 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.018 | 0.0566 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.018 | 0.0566 | 1 |
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.2253 | 1 | 1 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0097 | 0.0187 | 0.3299 |
Brugia malayi | Furin-like cysteine rich region family protein | 0.018 | 0.0566 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0058 | 0.0008 | 0.0145 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.018 | 0.0566 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0182 | 0.3117 |
Echinococcus granulosus | epidermal growth factor receptor | 0.018 | 0.0566 | 1 |
Trichomonas vaginalis | dihydrodipicolinate synthase, putative | 0.0113 | 0.0262 | 0.5 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.0097 | 0.0187 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0096 | 0.0182 | 0.3117 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 0.4 nM | Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR) | ChEMBL. | 10346932 |
IC50 (binding) | = 0.4 nM | Inhibition of phosphorylation of glutamic acid/tyrosine random copolymer by isolated epidermal growth factor receptor (EGFR) | ChEMBL. | 10346932 |
IC50 (binding) | = 9.9 nM | Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor (EGFR) in A431 cells | ChEMBL. | 10346932 |
IC50 (binding) | = 9.9 nM | Inhibition of EGF-stimulated autophosphorylation of epidermal growth factor receptor (EGFR) in A431 cells | ChEMBL. | 10346932 |
Inhibition (functional) | 0 | Irreversible inhibition of ATP binding site of EGFR (lack of phosphorylated EGFR) in A431 cells 8 hour after washing cells free of the inhibitor) | ChEMBL. | 10346932 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.