Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0158 | 0.4345 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.0104 | 0.2492 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0256 | 0.0092 |
Loa Loa (eye worm) | nucleolar RNA-associated protein alpha | 0.0324 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.207 | 0.207 |
Brugia malayi | RNA, U transporter 1 | 0.0086 | 0.1906 | 0.3809 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0158 | 0.4345 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0091 | 0.207 | 0.207 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0158 | 0.4345 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0158 | 0.4345 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0037 | 0.0212 | 0.0488 |
Plasmodium vivax | protease, putative | 0.0037 | 0.0212 | 0.0488 |
Onchocerca volvulus | 0.0091 | 0.207 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0324 | 1 | 1 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0158 | 0.4345 | 1 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0158 | 0.4345 | 0.4345 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0054 | 0.082 | 0.147 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.0177 | 0.5003 | 0.5 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0158 | 0.4345 | 1 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.0104 | 0.2492 | 0.2492 |
Toxoplasma gondii | hypothetical protein | 0.0054 | 0.082 | 0.1886 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) | 0.0104 | 0.2492 | 0.4744 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0054 | 0.082 | 0.1886 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.0177 | 0.5003 | 0.5003 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.0177 | 0.5003 | 1 |
Toxoplasma gondii | hypothetical protein | 0.0037 | 0.0212 | 0.0488 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0158 | 0.4345 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0091 | 0.207 | 0.207 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0038 | 0.0256 | 0.0256 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.0177 | 0.5003 | 0.5003 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.0177 | 0.5003 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0038 | 0.0256 | 0.0256 |
Entamoeba histolytica | CAAX prenyl protease family | 0.0177 | 0.5003 | 1 |
Echinococcus multilocularis | snurportin 1 | 0.0324 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0256 | 0.0092 |
Brugia malayi | CAAX amino terminal protease family protein | 0.0177 | 0.5003 | 1 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0177 | 0.5003 | 0.5003 |
Plasmodium falciparum | protease, putative | 0.0037 | 0.0212 | 0.0488 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.0177 | 0.5003 | 0.5003 |
Echinococcus granulosus | peptidase Clp S14 family | 0.0104 | 0.2492 | 0.2492 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0054 | 0.082 | 0.1886 |
Toxoplasma gondii | CAAX amino terminal protease family protein | 0.0037 | 0.0212 | 0.0488 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0256 | 0.0092 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.0104 | 0.2492 | 1 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.0177 | 0.5003 | 0.5 |
Brugia malayi | Probable ClpP-like protease | 0.0158 | 0.4345 | 0.8686 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.0177 | 0.5003 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0038 | 0.0256 | 0.0092 |
Brugia malayi | hypothetical protein | 0.0038 | 0.0256 | 0.0512 |
Loa Loa (eye worm) | hypothetical protein | 0.0158 | 0.4345 | 0.4345 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0158 | 0.4345 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0177 | 0.5003 | 0.5003 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0158 | 0.4345 | 0.5 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0158 | 0.4345 | 0.4345 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.0256 | 0.0256 |
Brugia malayi | Trypsin family protein | 0.0091 | 0.207 | 0.4139 |
Giardia lamblia | Hypothetical protein | 0.0177 | 0.5003 | 0.5 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0158 | 0.4345 | 0.4345 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0158 | 0.4345 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0038 | 0.0256 | 0.0256 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0158 | 0.4345 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0091 | 0.207 | 0.207 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.