Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0074 | 0.2957 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2957 | 0.2957 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2957 | 0.2957 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.1014 | 0.3429 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0022 | 0 | 0.5 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0058 | 0.2061 | 0.697 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0058 | 0.2061 | 0.697 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0022 | 0 | 0.5 |
Brugia malayi | RNA binding protein | 0.0074 | 0.2957 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0074 | 0.2957 | 0.2957 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2957 | 0.2957 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.004 | 0.1014 | 0.1014 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0 | 0.5 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0074 | 0.2957 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0058 | 0.2061 | 0.697 |
Echinococcus multilocularis | geminin | 0.0198 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0074 | 0.2957 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0022 | 0 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0022 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0022 | 0 | 0.5 |
Echinococcus multilocularis | tar DNA binding protein | 0.0074 | 0.2957 | 0.2957 |
Toxoplasma gondii | exonuclease III APE | 0.0022 | 0 | 0.5 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2957 | 0.2957 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0 | 0.5 |
Loa Loa (eye worm) | TAR-binding protein | 0.0074 | 0.2957 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0058 | 0.2061 | 0.697 |
Brugia malayi | TAR-binding protein | 0.0074 | 0.2957 | 1 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0022 | 0 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0022 | 0 | 0.5 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.004 | 0.1014 | 0.3429 |
Schistosoma mansoni | hypothetical protein | 0.0198 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0074 | 0.2957 | 0.2957 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.