Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | galactosylceramidase | No references |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Probable DNA topoisomerase II | 0.0159 | 0.1945 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0159 | 0.1945 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1194 | 0.6137 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0159 | 0.1945 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0447 | 0.6381 | 0.6292 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0159 | 0.1945 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0111 | 0.1194 | 0.1791 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0111 | 0.1194 | 0.1791 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0394 | 0.5564 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0111 | 0.1194 | 0.6137 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0159 | 0.1945 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0049 | 0.024 | 0.1235 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0159 | 0.1945 | 1 |
Brugia malayi | DNA topoisomerase III | 0.0049 | 0.024 | 0.1235 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0159 | 0.1945 | 0.3202 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0394 | 0.5564 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0394 | 0.5564 | 1 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0159 | 0.1945 | 0.1747 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0049 | 0.024 | 0.1235 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0159 | 0.1945 | 1 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0049 | 0.024 | 0.1235 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0237 | 0.1217 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0049 | 0.024 | 0.1235 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0682 | 1 | 1 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0111 | 0.1194 | 0.1791 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0111 | 0.1194 | 0.1791 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0159 | 0.1945 | 0.1747 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0682 | 1 | 0.5 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0049 | 0.024 | 0.1235 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0159 | 0.1945 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0237 | 0.1217 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0159 | 0.1945 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0159 | 0.1945 | 1 |
Brugia malayi | GRF zinc finger family protein | 0.0049 | 0.024 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0237 | 0.1217 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0682 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0111 | 0.1194 | 0.1791 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0682 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0394 | 0.5564 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0682 | 1 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0682 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0159 | 0.1945 | 1 |
Giardia lamblia | DNA topoisomerase II | 0.0138 | 0.1615 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0237 | 0.1217 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0394 | 0.5564 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0159 | 0.1945 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0235 | 0.3108 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 0.2512 uM | PubChem BioAssay. A Novel Cell-Based Assay to Identify Small Molecules for B -Galactocerebrosidase. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 39.8107 uM | PubChem BioAssay. qHTS of TDP-43 Inhibitors. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.