Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0313 | 0.5902 | 0.5 |
Brugia malayi | Probable DNA topoisomerase II | 0.0431 | 1 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0388 | 0.85 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0388 | 0.85 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0431 | 1 | 0.5 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0431 | 1 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0412 | 0.9342 | 0.5 |
Schistosoma mansoni | DNA topoisomerase II | 0.0431 | 1 | 0.5 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0431 | 1 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0313 | 0.5902 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0431 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0142 | 0 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0431 | 1 | 0.5 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0234 | 0.3184 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5096 | 0.4103 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0431 | 1 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0142 | 0 | 0.5 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0431 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0388 | 0.85 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0431 | 1 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0313 | 0.5902 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0388 | 0.85 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0142 | 0 | 0.5 |
Leishmania major | DNA topoisomerase ii | 0.0388 | 0.85 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0142 | 0 | 0.5 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0431 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0289 | 0.5096 | 0.4103 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.