Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0303 | 0.5902 | 0.5 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0417 | 1 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0137 | 0 | 0.5 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0137 | 0 | 0.5 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0417 | 1 | 0.5 |
Giardia lamblia | DNA topoisomerase II | 0.0399 | 0.9342 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0375 | 0.85 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0417 | 1 | 0.5 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0417 | 1 | 1 |
Schistosoma mansoni | DNA topoisomerase II | 0.0417 | 1 | 0.5 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0375 | 0.85 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0375 | 0.85 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0303 | 0.5902 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0303 | 0.5902 | 0.5 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0417 | 1 | 0.5 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0375 | 0.85 | 1 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0227 | 0.3184 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0417 | 1 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0417 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.5096 | 0.4103 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0417 | 1 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0417 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.028 | 0.5096 | 0.4103 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0417 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0375 | 0.85 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0137 | 0 | 0.5 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0137 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.