Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cytochrome P450, family 19, subfamily A, polypeptide 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Trypanosoma cruzi | cytochrome P450, putative | cytochrome P450, family 19, subfamily A, polypeptide 1 | 503 aa | 425 aa | 18.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Onchocerca volvulus | Uncharacterized serine carboxypeptidase homolog | 0.0808 | 1 | 1 |
Echinococcus granulosus | lysosomal protective protein | 0.0808 | 1 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0808 | 1 | 0.5 |
Trypanosoma cruzi | serine peptidase, Clan SC, Family S10, putative | 0.0808 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0808 | 1 | 1 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Schistosoma mansoni | family S10 unassigned peptidase (S10 family) | 0.0808 | 1 | 1 |
Brugia malayi | bZIP transcription factor family protein | 0.0084 | 0.0621 | 0.0621 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0808 | 1 | 0.5 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0084 | 0.0621 | 0.0621 |
Entamoeba histolytica | hypothetical protein | 0.0036 | 0 | 0.5 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0084 | 0.0621 | 0.0621 |
Schistosoma mansoni | lysosomal protective protein precursor (cathepsin A) (carboxypeptidase | 0.008 | 0.0569 | 0.0569 |
Leishmania major | serine carboxypeptidase (CBP1), putative,serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Echinococcus multilocularis | family S10 non peptidase ue (S10 family) | 0.0728 | 0.8966 | 0.8966 |
Brugia malayi | hypothetical protein | 0.0066 | 0.0388 | 0.0388 |
Echinococcus multilocularis | jun protein | 0.0084 | 0.0621 | 0.0621 |
Echinococcus granulosus | jun protein | 0.0084 | 0.0621 | 0.0621 |
Schistosoma mansoni | hypothetical protein | 0.0068 | 0.0417 | 0.0417 |
Schistosoma mansoni | family S10 non-peptidase homologue (S10 family) | 0.0808 | 1 | 1 |
Echinococcus multilocularis | lysosomal protective protein | 0.0808 | 1 | 1 |
Echinococcus granulosus | family S10 non peptidase ue S10 family | 0.0728 | 0.8966 | 0.8966 |
Schistosoma mansoni | jun-related protein | 0.0068 | 0.0417 | 0.0417 |
Trypanosoma brucei | serine peptidase, Clan SC, Family S10 | 0.0808 | 1 | 0.5 |
Trypanosoma cruzi | serine carboxypeptidase (CBP1), putative | 0.0808 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | 0 ug ml-1 | Effective concentration against HIV-1 replication in H9 lymphocytic cells; No suppression | ChEMBL. | 12729671 |
IC50 (binding) | > 12500 nM | Inhibition of human recombinant aromatase expressed in baculovirus infected insect cells using O-benzylfluorescein benzyl ester as substrate after 30 mins | ChEMBL. | No reference |
IC50 (functional) | = 1.77 ug ml-1 | Concentration that inhibits uninfected H9 cell growth by 50%. | ChEMBL. | 12729671 |
IC50 (functional) | = 1.77 ug ml-1 | Concentration that inhibits uninfected H9 cell growth by 50%. | ChEMBL. | 12729671 |
IC50 (binding) | > 500 uM | Inhibition of Influenza A virus (A/chicken/Korea/01310/2001 (H9N2)) neuraminidase after 30 mins by spectrofluorimetric analysis | ChEMBL. | 20886838 |
IC50 (binding) | > 500 uM | Inhibition of Influenza A virus (A/Sw/Kor/CAH1/04 (H1N1) KCTC 11165BP neuraminidase after 30 mins by spectrofluorimetric analysis | ChEMBL. | 20886838 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 12729671 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.