Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.005 | 1 | 0.5 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.005 | 1 | 1 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.005 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.005 | 1 | 1 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.005 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0044 | 0.7743 | 0.5 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0043 | 0.7352 | 0.6727 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0043 | 0.7352 | 0.6727 |
Chlamydia trachomatis | sulfite reductase | 0.0031 | 0.2407 | 0.5 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.005 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 1 | 1 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.005 | 1 | 0.5 |
Schistosoma mansoni | NADPH flavin oxidoreductase | 0.0025 | 0.0151 | 0.0151 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.005 | 1 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.005 | 1 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0044 | 0.7743 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.191 | 0.191 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.005 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.005 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.7352 | 0.6727 |
Schistosoma mansoni | cytochrome P450 reductase | 0.005 | 1 | 1 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.005 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.005 | 1 | 1 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.005 | 1 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.005 | 1 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.0031 | 0.2407 | 0.0615 |
Leishmania major | p450 reductase, putative | 0.005 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.005 | 1 | 0.5 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.005 | 1 | 0.5 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0031 | 0.2407 | 0.2407 |
Brugia malayi | FAD binding domain containing protein | 0.0031 | 0.2407 | 0.0615 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.005 | 1 | 0.5 |
Trichomonas vaginalis | sulfite reductase, putative | 0.005 | 1 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0043 | 0.7352 | 0.6727 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0025 | 0 | 0.5 |
Toxoplasma gondii | flavodoxin domain-containing protein | 0.0025 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.