Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, beta 3 | Starlite/ChEMBL | References |
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | Starlite/ChEMBL | References |
Homo sapiens | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_131775 | All targets in OG5_131775 |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_129441 | All targets in OG5_129441 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | gamma-aminobutyric acid (GABA) A receptor, alpha 2 | 451 aa | 393 aa | 25.9 % |
Brugia malayi | Neurotransmitter-gated ion-channel ligand binding domain containing protein | gamma-aminobutyric acid (GABA) A receptor, gamma 2 | 467 aa | 449 aa | 27.6 % |
Brugia malayi | excitatory GABA receptor EXP-1A | gamma-aminobutyric acid (GABA) A receptor, beta 3 | 473 aa | 441 aa | 29.9 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | aryl hydrocarbon receptor | 0.0155 | 0.2822 | 0.6938 |
Loa Loa (eye worm) | hypothetical protein | 0.0241 | 0.5189 | 0.3761 |
Echinococcus granulosus | geminin | 0.0201 | 0.4067 | 1 |
Schistosoma mansoni | aryl hydrocarbon receptor | 0.0209 | 0.4292 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0201 | 0.4067 | 0.9403 |
Brugia malayi | hypothetical protein | 0.0156 | 0.2839 | 0.5472 |
Schistosoma mansoni | hypothetical protein | 0.0162 | 0.299 | 0.655 |
Echinococcus multilocularis | jun protein | 0.0199 | 0.4018 | 0.988 |
Schistosoma mansoni | jun-related protein | 0.0162 | 0.299 | 0.655 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0199 | 0.4018 | 0.988 |
Brugia malayi | bZIP transcription factor family protein | 0.0199 | 0.4018 | 0.7744 |
Mycobacterium ulcerans | putative regulatory protein | 0.0053 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0137 | 0.2305 | 0.0022 |
Loa Loa (eye worm) | hypothetical protein | 0.0193 | 0.3868 | 0.2048 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0199 | 0.4018 | 0.988 |
Echinococcus granulosus | aryl hydrocarbon receptor | 0.0155 | 0.2822 | 0.6938 |
Echinococcus multilocularis | geminin | 0.0201 | 0.4067 | 1 |
Onchocerca volvulus | 0.0156 | 0.2839 | 1 | |
Schistosoma mansoni | hypothetical protein | 0.0201 | 0.4067 | 0.9403 |
Brugia malayi | PAS domain containing protein | 0.0072 | 0.0516 | 0.0995 |
Brugia malayi | aryl hydrocarbon receptor AHR-1 | 0.0136 | 0.2288 | 0.441 |
Loa Loa (eye worm) | hypothetical protein | 0.022 | 0.4614 | 0.3016 |
Loa Loa (eye worm) | hypothetical protein | 0.0155 | 0.2804 | 0.067 |
Onchocerca volvulus | 0.0155 | 0.2804 | 0.9876 | |
Brugia malayi | gamma-aminobutyric-acid receptor beta subunit precursor | 0.0241 | 0.5189 | 1 |
Echinococcus granulosus | jun protein | 0.0199 | 0.4018 | 0.988 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Ki (binding) | = 1.7 nM | Binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits in L(tk-) cells | ChEMBL. | 15027873 |
Ki (binding) | = 1.7 nM | Binding affinity for human GABA-A receptor alpha5-beta3-gamma2 subunits in L(tk-) cells | ChEMBL. | 15027873 |
Ki (binding) | = 2.4 nM | Binding affinity for human GABA-A receptor alpha3-beta3-gamma2 subunits in L(tk-) cells | ChEMBL. | 15027873 |
Ki (binding) | = 2.4 nM | Binding affinity for human GABA-A receptor alpha3-beta3-gamma2 subunits in L(tk-) cells | ChEMBL. | 15027873 |
Ki (binding) | = 3.7 nM | Binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits in L(tk-) cells | ChEMBL. | 15027873 |
Ki (binding) | = 3.7 nM | Binding affinity for human GABA-A receptor alpha2-beta3-gamma2 subunits in L(tk-) cells | ChEMBL. | 15027873 |
Ki (binding) | = 3.9 nM | Binding affinity for human GABA-A receptor alpha4-beta3-gamma2 subunits in L(tk-) cells | ChEMBL. | 15027873 |
Ki (binding) | = 3.9 nM | Binding affinity for human GABA-A receptor alpha4-beta3-gamma2 subunits in L(tk-) cells | ChEMBL. | 15027873 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.