Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | monoamine oxidase A | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | Get druggable targets OG5_130722 | All targets in OG5_130722 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | amine oxidase, flavin-containing family protein | monoamine oxidase A | 527 aa | 474 aa | 22.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Animal haem peroxidase family protein | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Mycobacterium tuberculosis | Probable flavin-containing monoamine oxidase AofH (amine oxidase) (MAO) | 0.0333 | 0 | 0.5 |
Brugia malayi | Blistered cuticle protein 3 | 0.0568 | 1 | 0.5 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0568 | 1 | 0.5 |
Echinococcus granulosus | peroxidasin | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0568 | 1 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0568 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0568 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0568 | 1 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Onchocerca volvulus | 0.0568 | 1 | 0.5 | |
Brugia malayi | Peroxidasin | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0568 | 1 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0568 | 1 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.1078 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Onchocerca volvulus | Dual oxidase homolog | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0568 | 1 | 0.5 |
Onchocerca volvulus | 0.0568 | 1 | 0.5 | |
Loa Loa (eye worm) | animal heme peroxidase | 0.0568 | 1 | 0.5 |
Schistosoma mansoni | peroxidasin | 0.0568 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0568 | 1 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0568 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Mycobacterium ulcerans | flavin-containing monoamine oxidase AofH | 0.0359 | 0.1078 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0568 | 1 | 0.5 |
Onchocerca volvulus | 0.0568 | 1 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | Inhibition of human recombinant MAOB expressed in BTI-TN-5B1-4 cells assessed as effect on H2O2 production from para-tyramine at 100 uM by fluorimetric method | ChEMBL. | 19267475 | |
IC50 (binding) | = 15.98 uM | Inhibition of human recombinant MAOA expressed in BTI-TN-5B1-4 cells assessed as effect on H2O2 production from para-tyramine by fluorimetric method | ChEMBL. | 19267475 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.