Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0123 | 0.3835 | 0.3342 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0177 | 0.6316 | 0.8491 |
Brugia malayi | CAAX amino terminal protease family protein | 0.01 | 0.2764 | 0.3226 |
Brugia malayi | Matrixin family protein | 0.0056 | 0.074 | 0.0864 |
Giardia lamblia | Hypothetical protein | 0.01 | 0.2764 | 0.5 |
Brugia malayi | Matrixin family protein | 0.0056 | 0.074 | 0.0864 |
Onchocerca volvulus | 0.0103 | 0.2893 | 0.2326 | |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0068 | 0.1294 | 0.5 |
Toxoplasma gondii | glycosyl hydrolase, family 31 protein | 0.0039 | 0 | 0.5 |
Onchocerca volvulus | 0.0079 | 0.1802 | 0.1147 | |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.074 | 0.0864 |
Echinococcus granulosus | CAAX prenyl protease 2 | 0.01 | 0.2764 | 0.3716 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.5185 | 1 |
Brugia malayi | Matrixin family protein | 0.0134 | 0.4343 | 0.5069 |
Echinococcus multilocularis | CAAX prenyl protease 2 | 0.01 | 0.2764 | 0.3716 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0682 | 0.0797 |
Loa Loa (eye worm) | matrixin family protein | 0.0123 | 0.3835 | 0.4476 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0682 | 0.0797 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.01 | 0.2764 | 0.533 |
Trypanosoma brucei | CAAX amino terminal protease, putative | 0.01 | 0.2764 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.0177 | 0.6316 | 0.7372 |
Schistosoma mansoni | matrix metallopeptidase-9 (M10 family) | 0.0132 | 0.4234 | 0.8165 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.074 | 0.0864 |
Trichomonas vaginalis | Clan U, family U48, CaaX prenyl peptidase 2-like | 0.01 | 0.2764 | 0.2764 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0682 | 0.0797 |
Schistosoma mansoni | alpha-glucosidase | 0.0153 | 0.5185 | 1 |
Echinococcus multilocularis | lysosomal alpha glucosidase | 0.0177 | 0.6316 | 0.8491 |
Loa Loa (eye worm) | matrixin family protein | 0.0134 | 0.4343 | 0.5069 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.0177 | 0.6316 | 0.7372 |
Brugia malayi | Pre-SET motif family protein | 0.0227 | 0.8568 | 1 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0223 | 0.8388 | 1 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.0202 | 0.7438 | 1 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0227 | 0.8568 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0068 | 0.1294 | 0.151 |
Schistosoma mansoni | hypothetical protein | 0.0079 | 0.1802 | 0.3475 |
Trypanosoma cruzi | peptidase with unknown catalytic mechanism (family U48) | 0.01 | 0.2764 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0682 | 0.0797 |
Leishmania major | CAAX prenyl protease 2, putative,peptidase with unknown catalytic mechanism (family U48) | 0.01 | 0.2764 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0056 | 0.074 | 0.1427 |
Loa Loa (eye worm) | hypothetical protein | 0.01 | 0.2764 | 0.3226 |
Schistosoma mansoni | family U48 unassigned peptidase (U48 family) | 0.01 | 0.2764 | 0.533 |
Brugia malayi | Matrixin family protein | 0.0056 | 0.074 | 0.0864 |
Entamoeba histolytica | CAAX prenyl protease family | 0.01 | 0.2764 | 1 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.0068 | 0.1294 | 0.151 |
Trichomonas vaginalis | set domain proteins, putative | 0.0258 | 1 | 1 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0056 | 0.074 | 0.0864 |
Trypanosoma cruzi | CAAX prenyl protease 2, putative | 0.01 | 0.2764 | 1 |
Echinococcus granulosus | lysosomal alpha glucosidase | 0.0177 | 0.6316 | 0.8491 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.074 | 0.0864 |
Mycobacterium ulcerans | hydrolase | 0.0068 | 0.1294 | 0.5 |
Onchocerca volvulus | Matrilysin homolog | 0.0123 | 0.3835 | 0.3342 |
Brugia malayi | Matrixin family protein | 0.0056 | 0.074 | 0.0864 |
Brugia malayi | Hemopexin family protein | 0.0079 | 0.1802 | 0.2103 |
Echinococcus granulosus | matrix metallopeptidase 7 M10 family | 0.0202 | 0.7438 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.