Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | matrixin family protein | 0.0227 | 0.1239 | 1 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.0209 | 0.1033 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.0209 | 0.1033 | 1 |
Loa Loa (eye worm) | matrixin family protein | 0.0209 | 0.1033 | 0.8334 |
Mycobacterium tuberculosis | Possible exported protein | 0.0516 | 0.4414 | 1 |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.0115 | 0 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.0133 | 0.0207 | 0.1666 |
Brugia malayi | Matrixin family protein | 0.0227 | 0.1239 | 1 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.1025 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0133 | 0.0207 | 0.5 |
Mycobacterium ulcerans | hydrolase | 0.0115 | 0 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.