Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | voltage-gated potassium channel | 0.0115 | 0.8881 | 0.9775 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0121 | 0.9446 | 0.9446 |
Echinococcus multilocularis | potassium voltage gated channel subfamily H | 0.0117 | 0.9085 | 0.9085 |
Mycobacterium ulcerans | ion transport protein | 0.0086 | 0.6168 | 0.5 |
Echinococcus granulosus | potassium voltage gated channel subfamily H | 0.0117 | 0.9085 | 0.9085 |
Schistosoma mansoni | voltage-gated potassium channel | 0.0121 | 0.9446 | 0.9446 |
Loa Loa (eye worm) | voltage and ligand gated potassium channel | 0.0117 | 0.9085 | 1 |
Echinococcus multilocularis | potassium voltage gated channel subfamily KQT | 0.0127 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0105 | 0.7966 | 0.5 |
Schistosoma mansoni | voltage-gated potassium channel KCNQ | 0.0127 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0112 | 0.8567 | 0.9429 |
Echinococcus granulosus | potassium channel KvQLT family member kqt 1 | 0.0127 | 1 | 1 |
Trichomonas vaginalis | voltage and ligand gated potassium channel, putative | 0.0105 | 0.7966 | 0.5 |
Brugia malayi | Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog | 0.0117 | 0.9085 | 0.9085 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.