Detailed information for compound 807136

Basic information

Technical information
  • TDR Targets ID: 807136
  • Name: 2-(2,4-dimethylphenoxy)-N-(2-nitrophenyl)acet amide
  • MW: 300.309 | Formula: C16H16N2O4
  • H donors: 1 H acceptors: 3 LogP: 3.91 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Nc1ccccc1[N+](=O)[O-])COc1ccc(cc1C)C
  • InChi: 1S/C16H16N2O4/c1-11-7-8-15(12(2)9-11)22-10-16(19)17-13-5-3-4-6-14(13)18(20)21/h3-9H,10H2,1-2H3,(H,17,19)
  • InChiKey: FZNDNNKXPVZQEN-UHFFFAOYSA-N  

Network

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Synonyms

  • 2-(2,4-dimethylphenoxy)-N-(2-nitrophenyl)ethanamide
  • Oprea1_184682
  • ZINC03959665
  • ST5182687
  • BIM-0006224.P001
  • CBMicro_006086

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Toxoplasma gondii hypothetical protein 0.0115 0.651 1
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0076 0.3131 0.5257
Trypanosoma cruzi GMP reductase 0.0076 0.3131 0.5257
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0076 0.3131 0.3111
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0109 0.5929 0.5917
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0076 0.3131 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0076 0.3131 0.5257
Plasmodium falciparum protein farnesyltransferase subunit alpha 0.0156 1 1
Giardia lamblia Prenyltransferase 0.0109 0.5929 0.5917
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0156 1 1
Echinococcus granulosus protein farnesyltransferase alpha subunit 0.0156 1 1
Schistosoma mansoni protein farnesyltransferase alpha subunit 0.0156 1 1
Entamoeba histolytica protein farnesyltransferase alpha subunit, putative 0.0156 1 1
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0076 0.3131 0.5257
Loa Loa (eye worm) hypothetical protein 0.0156 1 1
Echinococcus multilocularis protein farnesyltransferase alpha subunit 0.0156 1 1
Trypanosoma cruzi protein farnesyltransferase, putative 0.0109 0.5929 1
Plasmodium vivax prenyltransferase alpha subunit, putative 0.0156 1 1
Plasmodium vivax farnesyltransferase beta subunit, putative 0.0109 0.5929 0.5917
Trichomonas vaginalis protein farnesyltransferase alpha subunit, putative 0.0156 1 1
Trichomonas vaginalis geranylgeranyl transferase type beta subunit, putative 0.0109 0.5929 0.5917
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0076 0.3131 0.3111
Leishmania major farnesyltransferase beta subunit 0.0109 0.5929 1
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0109 0.5929 0.5917
Brugia malayi Prenyltransferase and squalene oxidase repeat family protein 0.0109 0.5929 0.5917
Toxoplasma gondii prenyltransferase and squalene oxidase repeat-containing protein 0.0109 0.5929 0.9104
Trichomonas vaginalis geranylgeranyl transferase type I beta subunit, putative 0.0109 0.5929 0.5917
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0076 0.3131 1
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0076 0.3131 1
Onchocerca volvulus 0.004 0.0029 0.5
Trypanosoma brucei protein farnesyltransferase beta subunit 0.0109 0.5929 1
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0072 0.2739 0.2718
Giardia lamblia Rab geranylgeranyltransferase 0.0156 1 1
Loa Loa (eye worm) IMP dehydrogenase 1 0.0076 0.3131 0.3111
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0072 0.2739 0.2718
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0115 0.651 0.65
Trypanosoma cruzi protein farnesyltransferase, putative 0.0109 0.5929 1
Trypanosoma brucei GMP reductase 0.0076 0.3131 0.5257
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0079 0.3382 0.3363
Schistosoma mansoni protein farnesyltransferase subunit beta 0.0109 0.5929 0.5917
Trypanosoma cruzi GMP reductase 0.0076 0.3131 0.5257
Trichomonas vaginalis protein farnesyltransferase alpha subunit/RAB geranylgeranyl transferase alpha subunit, putative 0.0156 1 1
Plasmodium falciparum protein farnesyltransferase subunit beta 0.0109 0.5929 0.5917
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0076 0.3131 0.3111
Echinococcus granulosus protein farnesyltransferase subunit beta 0.0109 0.5929 0.5917
Trichomonas vaginalis type I geranylgeranyltransferase beta subunit, putative 0.0109 0.5929 0.5917
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0076 0.3131 0.5
Loa Loa (eye worm) prenyltransferase and squalene oxidase repeat family protein 0.0109 0.5929 0.5917
Trichomonas vaginalis geranylgeranyl transferase type II beta subunit, putative 0.0109 0.5929 0.5917
Toxoplasma gondii IMP dehydrogenas 0.0076 0.3131 0.4786
Loa Loa (eye worm) prenyltransferase alpha subunit repeat containing protein 0.0156 1 1
Entamoeba histolytica protein farnesyltransferase beta subunit, putative 0.0109 0.5929 0.5917
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0076 0.3131 0.5257
Leishmania major guanosine monophosphate reductase 0.0076 0.3131 0.5257
Leishmania major inosine-5-monophosphate dehydrogenase 0.0076 0.3131 0.5257
Echinococcus multilocularis protein farnesyltransferase subunit beta 0.0109 0.5929 0.5917
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0076 0.3131 0.3111

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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