Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | alpha-glucosidase | 0.0999 | 0.6429 | 1 |
Loa Loa (eye worm) | glycosyl hydrolase family 31 protein | 0.1054 | 0.6974 | 1 |
Schistosoma mansoni | alpha-glucosidase | 0.0999 | 0.6429 | 1 |
Mycobacterium ulcerans | alpha-L-fucosidase | 0.1355 | 1 | 0.5 |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0359 | 0 | 0.5 |
Onchocerca volvulus | 0.0827 | 0.4697 | 0.5 | |
Trichomonas vaginalis | alpha-L-fucosidase, putative | 0.0359 | 0 | 0.5 |
Echinococcus multilocularis | fucosidase, alpha L 1, tissue | 0.1355 | 1 | 1 |
Brugia malayi | Glycosyl hydrolases family 31 protein | 0.1054 | 0.6974 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
MIC (functional) | = 1 ug ml-1 | In vitro antibacterial activity of the compound was tested against Haemophilus influenzae Q1 | ChEMBL. | 10406653 |
MIC (functional) | = 8 ug ml-1 | In vitro antibacterial activity of the compound was tested against Streptococcus pyogenes CN10 | ChEMBL. | 10406653 |
MIC (functional) | = 8 ug ml-1 | In vitro antibacterial activity of the compound was tested against Streptococcus pneumoniae PU7 | ChEMBL. | 10406653 |
MIC (functional) | = 16 ug ml-1 | In vitro antibacterial activity of the compound was tested against Moraxella catarrhalis 1502 | ChEMBL. | 10406653 |
MIC (functional) | = 128 ug ml-1 | In vitro antibacterial activity of the compound was tested against Staphylococcus aureus Oxford | ChEMBL. | 10406653 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.