Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Guanylyl cyclase protein 23 | 0.0425 | 0.0577 | 0.0714 |
Schistosoma mansoni | tyrosine kinase | 0.0425 | 0.0577 | 0.0626 |
Echinococcus granulosus | GPCR family 3 C terminal | 0.0734 | 0.1143 | 0.1143 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0425 | 0.0577 | 0.0577 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0425 | 0.0577 | 0.0577 |
Brugia malayi | Metabotropic glutamate receptor precursor. | 0.4519 | 0.8085 | 1 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0123 | 0.0025 | 0.0025 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.0577 | 0.0577 |
Loa Loa (eye worm) | glutamate receptor | 0.4519 | 0.8085 | 0.8085 |
Echinococcus multilocularis | tyrosine kinase | 0.0425 | 0.0577 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.0577 | 0.0577 |
Echinococcus multilocularis | receptor type guanylyl cyclase | 0.0425 | 0.0577 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.0577 | 0.0577 |
Loa Loa (eye worm) | glutamate receptor | 0.1778 | 0.3058 | 0.3058 |
Loa Loa (eye worm) | hypothetical protein | 0.5564 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0425 | 0.0577 | 0.0626 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0425 | 0.0577 | 0.0577 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0425 | 0.0577 | 0.0577 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.3786 | 0.674 | 0.731 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0425 | 0.0577 | 0.0577 |
Loa Loa (eye worm) | metabotropic glutamate receptor 8 | 0.0425 | 0.0577 | 0.0577 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0425 | 0.0577 | 0.0577 |
Echinococcus granulosus | tyrosine kinase | 0.0425 | 0.0577 | 0.0577 |
Echinococcus granulosus | glutamate receptor 2 | 0.0425 | 0.0577 | 0.0577 |
Onchocerca volvulus | Atrial natriuretic peptide receptor 3 homolog | 0.0425 | 0.0577 | 0.5051 |
Echinococcus granulosus | atrial natriuretic peptide receptor | 0.0425 | 0.0577 | 0.0577 |
Schistosoma mansoni | metabotropic glutamate receptor | 0.2203 | 0.3837 | 0.4162 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0734 | 0.1143 | 0.1414 |
Schistosoma mansoni | hypothetical protein | 0.0734 | 0.1143 | 0.124 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0425 | 0.0577 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.0577 | 0.0577 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.0577 | 0.0577 |
Echinococcus multilocularis | GPCR, family 3, C terminal | 0.0734 | 0.1143 | 0.1143 |
Loa Loa (eye worm) | metabotropic GABA-B receptor subtype 2 | 0.1158 | 0.1922 | 0.1922 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0425 | 0.0577 | 0.0577 |
Echinococcus multilocularis | metabotropic glutamate receptor 2 | 0.3786 | 0.674 | 0.674 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0425 | 0.0577 | 0.0577 |
Echinococcus granulosus | receptor type guanylyl cyclase | 0.0425 | 0.0577 | 0.0577 |
Schistosoma mansoni | tyrosine kinase | 0.0425 | 0.0577 | 0.0626 |
Entamoeba histolytica | hypothetical protein | 0.0425 | 0.0577 | 0.5 |
Schistosoma mansoni | metabotropic glutamate receptor 2 3 (mglur group 2) | 0.5139 | 0.9221 | 1 |
Onchocerca volvulus | Metabotropic glutamate receptor homolog | 0.0734 | 0.1143 | 1 |
Onchocerca volvulus | 0.0425 | 0.0577 | 0.5051 | |
Loa Loa (eye worm) | hypothetical protein | 0.0734 | 0.1143 | 0.1143 |
Brugia malayi | metabotropic glutamate receptor type 2 | 0.2203 | 0.3837 | 0.4746 |
Echinococcus granulosus | glutamate receptor 2 | 0.0425 | 0.0577 | 0.0577 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0425 | 0.0577 | 0.0626 |
Loa Loa (eye worm) | receptor family ligand binding region containing protein | 0.1158 | 0.1922 | 0.1922 |
Brugia malayi | metabotropic GABA-B receptor subtype 2 | 0.0425 | 0.0577 | 0.0714 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.0577 | 0.0577 |
Echinococcus granulosus | metabotropic glutamate receptor 2 | 0.3786 | 0.674 | 0.674 |
Schistosoma mansoni | lipoxygenase | 0.0123 | 0.0025 | 0.0027 |
Loa Loa (eye worm) | hypothetical protein | 0.0425 | 0.0577 | 0.0577 |
Onchocerca volvulus | 0.0425 | 0.0577 | 0.5051 | |
Loa Loa (eye worm) | hypothetical protein | 0.1158 | 0.1922 | 0.1922 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0425 | 0.0577 | 0.0577 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0425 | 0.0577 | 0.0577 |
Trypanosoma cruzi | extracellular receptor, putative | 0.0425 | 0.0577 | 0.5 |
Leishmania major | extracellular receptor, putative | 0.0425 | 0.0577 | 0.5 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0425 | 0.0577 | 0.0577 |
Echinococcus multilocularis | atrial natriuretic peptide receptor | 0.0425 | 0.0577 | 0.0577 |
Onchocerca volvulus | Poor gastrulation protein homolog | 0.0734 | 0.1143 | 1 |
Echinococcus multilocularis | metabotropic glutamate receptor 5 | 0.5564 | 1 | 1 |
Loa Loa (eye worm) | RGC/RGC protein kinase | 0.0425 | 0.0577 | 0.0577 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.0425 | 0.0577 | 0.0714 |
Brugia malayi | metabotropic glutamate receptor subtype 5a (mGluR5a), putative | 0.4094 | 0.7306 | 0.9036 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0425 | 0.0577 | 0.0577 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0425 | 0.0577 | 0.0577 |
Brugia malayi | hypothetical protein | 0.0425 | 0.0577 | 0.0714 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0123 | 0.0025 | 0.0025 |
Brugia malayi | Receptor family ligand binding region containing protein | 0.1158 | 0.1922 | 0.2378 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.