Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | plasminogen activator, urokinase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | Mastin | plasminogen activator, urokinase | 414 aa | 340 aa | 24.4 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | cysteine repeat modular protein 1 | 0.0035 | 0.0053 | 1 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAb [second part] (isocitrase) (isocitratase) (Icl) | 0.2401 | 1 | 1 |
Mycobacterium ulcerans | isocitrate lyase Icl | 0.2401 | 1 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0066 | 0.0183 | 1 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0066 | 0.0183 | 1 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0066 | 0.0183 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0035 | 0.0053 | 0.5 |
Mycobacterium tuberculosis | Probable isocitrate lyase AceAa [first part] (isocitrase) (isocitratase) (Icl) | 0.2401 | 1 | 1 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0066 | 0.0183 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0053 | 0.3251 |
Brugia malayi | Protein kinase domain containing protein | 0.0035 | 0.0053 | 0.2917 |
Plasmodium vivax | cysteine repeat modular protein 1, putative | 0.0035 | 0.0053 | 1 |
Mycobacterium ulcerans | isocitrate lyase AceAb | 0.2401 | 1 | 1 |
Echinococcus granulosus | tissue type plasminogen activator | 0.0035 | 0.0053 | 0.2917 |
Loa Loa (eye worm) | TK/ROR protein kinase | 0.0035 | 0.0053 | 0.3251 |
Toxoplasma gondii | kringle domain-containing protein | 0.0035 | 0.0053 | 0.5 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0064 | 0.0172 | 0.9426 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0053 | 0.2917 |
Leishmania major | 3-oxoacyl-(acyl-carrier protein) reductase, putative | 0.0066 | 0.0183 | 1 |
Mycobacterium tuberculosis | Isocitrate lyase Icl (isocitrase) (isocitratase) | 0.2401 | 1 | 1 |
Schistosoma mansoni | lipoxygenase | 0.0064 | 0.0172 | 0.9426 |
Brugia malayi | Kringle domain containing protein | 0.0035 | 0.0053 | 0.2917 |
Onchocerca volvulus | 0.0035 | 0.0053 | 1 | |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0062 | 0.0164 | 1 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0064 | 0.0172 | 0.9426 |
Echinococcus multilocularis | tissue type plasminogen activator | 0.0035 | 0.0053 | 0.2917 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | < 50 % | Ability to inhibit plasmin using human plasmin (quadratech) and Chromozym-PL (boehringer) as substrate at concentration of 100 microM | ChEMBL. | 11755350 |
Inhibition (binding) | < 50 % | Ability to inhibit plasmin using human plasmin (quadratech) and Chromozym-PL (boehringer) as substrate at concentration of 100 microM | ChEMBL. | 11755350 |
Ki (binding) | = 0.17 uM | In vitro inhibition of human urokinase Plasminogen Activator. | ChEMBL. | 11755350 |
Ki (binding) | = 0.17 uM | In vitro inhibition of human urokinase Plasminogen Activator. | ChEMBL. | 11755350 |
Ki (binding) | = 52 uM | Ability to inhibit tissue plasminogen activator (quadratech) and S-2444 as substrate | ChEMBL. | 11755350 |
Ki (binding) | = 52 uM | Ability to inhibit tissue plasminogen activator (quadratech) and S-2444 as substrate | ChEMBL. | 11755350 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.