Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | sulfite reductase, putative | 0.005 | 0.1552 | 1 |
Chlamydia trachomatis | sulfite reductase | 0.0031 | 0.0356 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.005 | 0.1552 | 0.1241 |
Leishmania major | p450 reductase, putative | 0.005 | 0.1552 | 0.0404 |
Leishmania major | hypothetical protein, unknown function | 0.0186 | 1 | 1 |
Echinococcus granulosus | NADPH dependent diflavin oxidoreductase 1 | 0.005 | 0.1552 | 0.1241 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.005 | 0.1552 | 0.5 |
Giardia lamblia | Nitric oxide synthase, inducible | 0.0045 | 0.1197 | 0.5 |
Schistosoma mansoni | cytochrome P450 reductase | 0.005 | 0.1552 | 0.1552 |
Schistosoma mansoni | ngng-dimethylarginine dimethylaminohydrolase | 0.0186 | 1 | 1 |
Brugia malayi | FAD binding domain containing protein | 0.005 | 0.1552 | 0.1241 |
Echinococcus granulosus | ng dimethylarginine dimethylaminohydrolase | 0.0186 | 1 | 1 |
Echinococcus multilocularis | ng dimethylarginine dimethylaminohydrolase | 0.0186 | 1 | 1 |
Onchocerca volvulus | 0.0186 | 1 | 0.5 | |
Giardia lamblia | Hypothetical protein | 0.0045 | 0.1197 | 0.5 |
Leishmania major | hypothetical protein, unknown function | 0.0186 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.005 | 0.1552 | 0.5 |
Trypanosoma cruzi | NADPH-dependent FMN/FAD containing oxidoreductase, putative | 0.005 | 0.1552 | 0.5 |
Trypanosoma cruzi | p450 reductase, putative | 0.005 | 0.1552 | 0.5 |
Schistosoma mansoni | ngng-dimethylarginine dimethylaminohydrolase | 0.0186 | 1 | 1 |
Mycobacterium ulcerans | formate dehydrogenase H FdhF | 0.005 | 0.1552 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0186 | 1 | 1 |
Trypanosoma brucei | NADPH-cytochrome p450 reductase, putative | 0.005 | 0.1552 | 0.5 |
Loa Loa (eye worm) | FAD binding domain-containing protein | 0.005 | 0.1552 | 0.1241 |
Echinococcus granulosus | NADPH cytochrome P450 reductase | 0.005 | 0.1552 | 0.1241 |
Leishmania major | NADPH-cytochrome p450 reductase-like protein | 0.005 | 0.1552 | 0.0404 |
Echinococcus multilocularis | NADPH dependent diflavin oxidoreductase 1 | 0.005 | 0.1552 | 0.1241 |
Schistosoma mansoni | 5-methyl tetrahydrofolate-homocysteine methyltransferase reductase | 0.0031 | 0.0356 | 0.0356 |
Plasmodium falciparum | nitric oxide synthase, putative | 0.005 | 0.1552 | 0.5 |
Plasmodium vivax | NADPH-cytochrome p450 reductase, putative | 0.005 | 0.1552 | 1 |
Trypanosoma brucei | NADPH--cytochrome P450 reductase, putative | 0.005 | 0.1552 | 0.5 |
Trypanosoma brucei | NADPH-dependent diflavin oxidoreductase 1 | 0.005 | 0.1552 | 0.5 |
Trypanosoma cruzi | cytochrome P450 reductase, putative | 0.005 | 0.1552 | 0.5 |
Echinococcus multilocularis | NADPH cytochrome P450 reductase | 0.005 | 0.1552 | 0.1241 |
Brugia malayi | flavodoxin family protein | 0.005 | 0.1552 | 0.1241 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.