Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | hypothetical protein | 0.0215 | 0.3993 | 0.3436 |
Plasmodium falciparum | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0037 | 0.0006 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0054 | 0.0385 | 0.0385 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0483 | 1 | 1 |
Brugia malayi | Augmenter of liver regeneration | 0.0037 | 0.0006 | 0.0006 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0075 | 0.0849 | 0.0849 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0075 | 0.0849 | 0.0844 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0054 | 0.0385 | 0.0385 |
Trypanosoma brucei | poly(ADP-ribose) glycohydrolase, putative | 0.0483 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0054 | 0.0385 | 0.0385 |
Brugia malayi | hypothetical protein | 0.0075 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | DnaJ domain-containing protein | 0.0067 | 0.0663 | 0.0663 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0037 | 0.0006 | 0.0006 |
Plasmodium vivax | FAD-linked sulfhydryl oxidase ERV1, putative | 0.0037 | 0.0006 | 0.5 |
Schistosoma mansoni | poly(ADP-ribose) glycohydrolase | 0.0483 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0054 | 0.0385 | 0.0385 |
Trichomonas vaginalis | protein kinase inhibitor, putative | 0.0067 | 0.0663 | 0.5 |
Brugia malayi | DnaJ domain containing protein | 0.0067 | 0.0663 | 0.0663 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0483 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0067 | 0.0663 | 0.0663 |
Entamoeba histolytica | hypothetical protein | 0.0483 | 1 | 1 |
Echinococcus multilocularis | dnaJ subfamily C 6 | 0.0067 | 0.0663 | 0.0658 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0215 | 0.3993 | 0.3436 |
Echinococcus granulosus | dnaJ subfamily C 6 | 0.0067 | 0.0663 | 0.0658 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0215 | 0.3993 | 0.399 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0075 | 0.0849 | 0.0844 |
Echinococcus multilocularis | poly(ADP ribose) glycohydrolase | 0.0483 | 1 | 1 |
Leishmania major | hypothetical protein, conserved | 0.0037 | 0.0006 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0075 | 0.0849 | 0.0849 |
Loa Loa (eye worm) | Poly(ADP-ribose) glycohydrolase | 0.0483 | 1 | 1 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0483 | 1 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0483 | 1 | 1 |
Echinococcus granulosus | polyADP ribose glycohydrolase | 0.0483 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.