Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0073 | 0.0494 | 0.049 |
Trichomonas vaginalis | protein kinase inhibitor, putative | 0.0124 | 0.1177 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0146 | 0.1471 | 0.2415 |
Schistosoma mansoni | peptidase Clp (S14 family) | 0.0076 | 0.0528 | 0.0867 |
Brugia malayi | DnaJ domain containing protein | 0.0124 | 0.1177 | 0.1932 |
Echinococcus granulosus | peptidase Clp S14 family | 0.005 | 0.018 | 0.029 |
Treponema pallidum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0528 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0124 | 0.1177 | 0.1932 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0528 | 0.0862 |
Brugia malayi | Poly | 0.0491 | 0.6091 | 1 |
Mycobacterium leprae | PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) | 0.0076 | 0.0528 | 1 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0491 | 0.6091 | 1 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0528 | 0.5 |
Loa Loa (eye worm) | hepatopoietin HPO2 | 0.0036 | 0.0003 | 0.0005 |
Leishmania major | hypothetical protein, conserved | 0.0036 | 0.0003 | 0.5 |
Brugia malayi | hypothetical protein | 0.0146 | 0.1471 | 0.2415 |
Brugia malayi | Probable ClpP-like protease | 0.0076 | 0.0528 | 0.0867 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0073 | 0.0494 | 0.0805 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0491 | 0.6091 | 1 |
Brugia malayi | hypothetical protein | 0.0073 | 0.0494 | 0.081 |
Echinococcus multilocularis | dnaJ subfamily C 6 | 0.0124 | 0.1177 | 0.1174 |
Wolbachia endosymbiont of Brugia malayi | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0528 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0073 | 0.0494 | 0.081 |
Schistosoma mansoni | poly(ADP-ribose) glycohydrolase | 0.0491 | 0.6091 | 1 |
Plasmodium vivax | ATP-dependent Clp protease proteolytic subunit, putative | 0.0076 | 0.0528 | 1 |
Plasmodium falciparum | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0528 | 1 |
Brugia malayi | Augmenter of liver regeneration | 0.0036 | 0.0003 | 0.0005 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1708 | 0.2804 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0491 | 0.6091 | 1 |
Echinococcus multilocularis | geminin | 0.0164 | 0.1708 | 0.1705 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0223 | 0.0367 |
Entamoeba histolytica | hypothetical protein | 0.0219 | 0.2445 | 0.3487 |
Echinococcus granulosus | polyADP ribose glycohydrolase | 0.0491 | 0.6091 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0491 | 0.6091 | 1 |
Loa Loa (eye worm) | Poly(ADP-ribose) glycohydrolase | 0.0491 | 0.6091 | 1 |
Trypanosoma cruzi | poly(ADP-ribose) glycohydrolase, putative | 0.0491 | 0.6091 | 1 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) | 0.005 | 0.018 | 0.5 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0073 | 0.0494 | 0.081 |
Loa Loa (eye worm) | hypothetical protein | 0.0076 | 0.0528 | 0.0867 |
Echinococcus multilocularis | peptidase Clp (S14 family) | 0.005 | 0.018 | 0.0177 |
Entamoeba histolytica | poly(ADP-ribose) glycohydrolase, putative | 0.0219 | 0.2445 | 0.3487 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0528 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0223 | 0.0367 |
Loa Loa (eye worm) | DnaJ domain-containing protein | 0.0124 | 0.1177 | 0.1932 |
Toxoplasma gondii | poly(ADP-ribose) glycohydrolase | 0.0219 | 0.2445 | 0.4012 |
Echinococcus multilocularis | poly(ADP ribose) glycohydrolase | 0.0491 | 0.6091 | 0.6089 |
Echinococcus granulosus | dnaJ subfamily C 6 | 0.0124 | 0.1177 | 0.1928 |
Echinococcus granulosus | geminin | 0.0164 | 0.1708 | 0.28 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0223 | 0.0367 |
Mycobacterium ulcerans | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0528 | 0.5 |
Mycobacterium tuberculosis | Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) | 0.005 | 0.018 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0164 | 0.1708 | 0.2804 |
Echinococcus granulosus | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0528 | 0.0862 |
Echinococcus multilocularis | ATP dependent Clp protease proteolytic subunit | 0.0076 | 0.0528 | 0.0525 |
Trypanosoma brucei | poly(ADP-ribose) glycohydrolase, putative | 0.0491 | 0.6091 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0223 | 0.0367 |
Chlamydia trachomatis | ATP-dependent Clp protease proteolytic subunit | 0.0076 | 0.0528 | 0.5 |
Toxoplasma gondii | ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein | 0.0076 | 0.0528 | 0.0862 |
Onchocerca volvulus | 0.0146 | 0.1471 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.