Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) | Starlite/ChEMBL | References |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0032 | 0.0019 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0027 | 0 | 0.5 |
Mycobacterium ulcerans | malate synthase G | 0.2253 | 1 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0019 | 1 |
Toxoplasma gondii | dihydrodipicolinate synthase | 0.0113 | 0.0386 | 1 |
Trichomonas vaginalis | dihydrodipicolinate synthase, putative | 0.0113 | 0.0386 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0019 | 1 |
Onchocerca volvulus | 0.0032 | 0.0019 | 0.5 | |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.0019 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrodipicolinate synthase | 0.0113 | 0.0386 | 0.5 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.0019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0019 | 1 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.0019 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Schistosoma mansoni | peroxidasin | 0.0032 | 0.0019 | 1 |
Mycobacterium tuberculosis | Malate synthase G GlcB | 0.2253 | 1 | 1 |
Brugia malayi | hypothetical protein | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0032 | 0.0019 | 0.5 |
Plasmodium falciparum | carbonic anhydrase | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.0019 | 0.5 | |
Brugia malayi | Peroxidasin | 0.0032 | 0.0019 | 1 |
Echinococcus granulosus | peroxidasin | 0.0032 | 0.0019 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Chlamydia trachomatis | 4-hydroxy-tetrahydrodipicolinate synthase | 0.0113 | 0.0386 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0032 | 0.0019 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0019 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0027 | 0 | 0.5 |
Onchocerca volvulus | 0.0032 | 0.0019 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0027 | 0 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0019 | 1 |
Brugia malayi | Blistered cuticle protein 3 | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Echinococcus multilocularis | peroxidasin | 0.0032 | 0.0019 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.0019 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0032 | 0.0019 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0032 | 0.0019 | 0.5 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0027 | 0 | 0.5 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0032 | 0.0019 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0032 | 0.0019 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 51 | In vivo oral activity by air pouch assay on Sprague-Dawley rats at dose 2 mg/kg administered intragastrically in a volume of 5 mL/kg 2 hr prior to injection. | ChEMBL. | 8627608 |
IC50 (binding) | = 7.64 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
IC50 (binding) | = 0.023 uM | In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2 | ChEMBL. | 8627608 |
IC50 (binding) | = 0.023 uM | In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 2 | ChEMBL. | 8627608 |
IC50 (binding) | > 100 uM | In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 1. | ChEMBL. | 8627608 |
IC50 (binding) | > 100 uM | In vitro inhibitory activity against human recombinant prostaglandin G/H synthase 1. | ChEMBL. | 8627608 |
Log IC50 (binding) | = 7.64 | Inhibition of human Prostaglandin G/H synthase 2 | ChEMBL. | 11563921 |
Selectivity (binding) | > 4300 | Ratio of inhibitory concentration of COX-1 and COX-2 measured for their oral activity in an acute inflammation model | ChEMBL. | 8627608 |
Selectivity (binding) | > 4300 | Ratio of inhibitory concentration of COX-1 and COX-2 measured for their oral activity in an acute inflammation model | ChEMBL. | 8627608 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.