Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0077 | 0.7347 | 1 | |
Echinococcus granulosus | jun protein | 0.0098 | 1 | 1 |
Echinococcus multilocularis | jun protein | 0.0098 | 1 | 1 |
Schistosoma mansoni | jun-related protein | 0.008 | 0.7685 | 1 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription factor | 0.0098 | 1 | 1 |
Schistosoma mansoni | hypothetical protein | 0.008 | 0.7685 | 1 |
Brugia malayi | hypothetical protein | 0.0077 | 0.7347 | 0.7347 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription factor | 0.0098 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0095 | 0.9661 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
clogP | = 2.48 | Calculated partition coefficient (clogP) (PALLAS 2.0) | ChEMBL. | 10956193 |
ED50 (functional) | = 6.82 uM | In vivo anticonvulsant activity was measured as median effective dose required to prevent tonic phase of seizure in DBA/2 mice | ChEMBL. | 15027880 |
ED50 (functional) | = 6.82 uM | In vivo anticonvulsant activity was measured as median effective dose required to prevent tonic phase of seizure in DBA/2 mice | ChEMBL. | 15027880 |
ED50 (functional) | = 15.8 uM | In vivo anticonvulsant activity was measured as median effective dose required to prevent clonic phase of seizure in DBA/2 mice | ChEMBL. | 15027880 |
ED50 (functional) | = 15.8 uM | In vivo anticonvulsant activity was measured as median effective dose required to prevent clonic phase of seizure in DBA/2 mice | ChEMBL. | 15027880 |
ED50 (functional) | = 6.82 uM kg-1 | Anticonvulsant activity against audiogenic seizures in DBA/2 mice expressed as ED50 values in tonic phase | ChEMBL. | 10956193 |
ED50 (functional) | = 15.8 uM kg-1 | Anticonvulsant activity against audiogenic seizures in DBA/2 mice expressed as ED50 values in clonic phase | ChEMBL. | 10956193 |
Protective index (ADMET) | = 3.3 | Ratio between TD50 and ED50 from the clonic phase of audiogenic seizures | ChEMBL. | 10956193 |
Rm | = -0.126 | Relative lipophilicity of the compound expressed as Rm value | ChEMBL. | 10956193 |
TD50 (ADMET) | = 52.8 uM kg-1 | Toxic dose of the compound was determined in DBA/2 mice | ChEMBL. | 10956193 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.