Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Ribonuclease 2-5A family protein | 0.0202 | 0.533 | 0.5261 |
Echinococcus multilocularis | serine:threonine protein kinase:endoribonuclease | 0.0202 | 0.533 | 0.533 |
Echinococcus granulosus | melanoma receptor tyrosine protein kinase | 0.016 | 0.3299 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.3217 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.3217 | 0.3117 |
Echinococcus multilocularis | insulin growth factor 1 receptor beta | 0.0095 | 0.0145 | 0.0145 |
Echinococcus granulosus | serine:threonine protein kinase:endoribonuclease | 0.0202 | 0.533 | 0.5261 |
Echinococcus granulosus | epidermal growth factor receptor | 0.016 | 0.3299 | 0.32 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0104 | 0.0548 | 0.0409 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.016 | 0.3299 | 0.3299 |
Echinococcus multilocularis | epidermal growth factor receptor | 0.0299 | 1 | 1 |
Entamoeba histolytica | protein kinase, putative | 0.0202 | 0.533 | 0.5 |
Loa Loa (eye worm) | TK/EGFR protein kinase | 0.0299 | 1 | 1 |
Echinococcus multilocularis | insulin receptor | 0.0095 | 0.0145 | 0.0145 |
Echinococcus granulosus | epidermal growth factor receptor | 0.0299 | 1 | 1 |
Schistosoma mansoni | tyrosine kinase | 0.016 | 0.3299 | 0.32 |
Schistosoma mansoni | tyrosine kinase | 0.0299 | 1 | 1 |
Loa Loa (eye worm) | IRE protein kinase | 0.0202 | 0.533 | 0.5261 |
Entamoeba histolytica | protein kinase, putative | 0.0202 | 0.533 | 0.5 |
Trichomonas vaginalis | serine threonine-protein kinase, putative | 0.0103 | 0.0517 | 0.5 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0103 | 0.0517 | 0.5 |
Schistosoma mansoni | tyrosine kinase | 0.0159 | 0.3217 | 0.3117 |
Schistosoma mansoni | tyrosine kinase | 0.016 | 0.3299 | 0.32 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.