Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | voltage-dependent calcium channel beta 2a subunit | 0.0331 | 0.3756 | 1 |
Echinococcus multilocularis | geminin | 0.0168 | 0.1579 | 0.1069 |
Schistosoma mansoni | high voltage-activated calcium channel beta subunit 2 | 0.0161 | 0.1485 | 0.9071 |
Echinococcus multilocularis | high voltage activated calcium channel beta | 0.0161 | 0.1485 | 0.0969 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0092 | 0.0572 | 0.1522 |
Brugia malayi | Voltage-dependent L-type calcium channel beta-2 subunit | 0.0331 | 0.3756 | 1 |
Echinococcus granulosus | high voltage activated calcium channel beta | 0.0161 | 0.1485 | 0.9071 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0092 | 0.0572 | 0.1522 |
Echinococcus granulosus | geminin | 0.0168 | 0.1579 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1579 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0168 | 0.1579 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.