Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | muscleblind-like splicing regulator 1 | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Brugia malayi | Muscleblind-like protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus granulosus | muscleblind protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Loa Loa (eye worm) | hypothetical protein | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Echinococcus multilocularis | muscleblind protein 1 | Get druggable targets OG5_132352 | All targets in OG5_132352 |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | 0.0277 | 0.0266 | 1 | |
Mycobacterium ulcerans | phosphoribosylamine--glycine ligase | 0.0975 | 0.2034 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0266 | 1 |
Mycobacterium tuberculosis | Probable phosphoribosylformylglycinamidine CYCLO-ligase PurM (AIRS) (phosphoribosyl-aminoimidazole synthetase) (air synthase) | 0.0215 | 0.0111 | 0.5 |
Onchocerca volvulus | 0.0277 | 0.0266 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0266 | 1 |
Onchocerca volvulus | 0.0277 | 0.0266 | 1 | |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0266 | 1 |
Entamoeba histolytica | hypothetical protein | 0.0277 | 0.0266 | 0.5 |
Brugia malayi | Reduced folate carrier family protein | 0.0277 | 0.0266 | 1 |
Echinococcus multilocularis | folate receptor beta | 0.4122 | 1 | 1 |
Onchocerca volvulus | 0.0215 | 0.0111 | 0.4158 | |
Giardia lamblia | Hypothetical protein | 0.0277 | 0.0266 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0266 | 1 |
Echinococcus granulosus | Major facilitator superfamily general substrate transporter | 0.0982 | 0.2053 | 0.2035 |
Schistosoma mansoni | hypothetical protein | 0.0981 | 0.2049 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0266 | 1 |
Brugia malayi | folate-like transporter 3 | 0.0277 | 0.0266 | 1 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0277 | 0.0266 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0277 | 0.0266 | 1 |
Onchocerca volvulus | 0.0277 | 0.0266 | 1 | |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0277 | 0.0266 | 1 |
Loa Loa (eye worm) | reduced folate carrier family protein | 0.0277 | 0.0266 | 1 |
Onchocerca volvulus | Folate transporter 1 homolog | 0.0277 | 0.0266 | 1 |
Echinococcus multilocularis | Major facilitator superfamily, general substrate transporter | 0.0982 | 0.2053 | 0.2035 |
Mycobacterium leprae | PROBABLE PHOSPHORIBOSYLAMINE--GLYCINE LIGASE PURD (GARS) (GLYCINAMIDE RIBONUCLEOTIDE SYNTHETASE) (PHOSPHORIBOSYLGLYCINAMIDE SYNT | 0.0975 | 0.2034 | 1 |
Toxoplasma gondii | hypothetical protein | 0.1013 | 0.2131 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | phosphoribosylamine--glycine ligase | 0.0975 | 0.2034 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | 4.4668 uM | PubChem BioAssay. qHTS Assay for Inhibitors of MBNL1-poly(CUG) RNA binding. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.