Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Echinococcus granulosus | Transglutaminase | 0.0037 | 1 | 1 |
Mycobacterium ulcerans | putative transglutaminase-like protein | 0.0037 | 1 | 1 |
Mycobacterium ulcerans | transglutaminase family protein | 0.0037 | 1 | 1 |
Giardia lamblia | Hypothetical protein | 0.0037 | 1 | 1 |
Mycobacterium tuberculosis | Conserved protein | 0.0037 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0037 | 1 | 0.5 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 1 | 1 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0037 | 1 | 1 |
Echinococcus multilocularis | Transglutaminase | 0.0037 | 1 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0037 | 1 | 1 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.002 | 0 | 0.5 |
Mycobacterium tuberculosis | Long conserved protein | 0.0037 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0 | 0.5 |
Mycobacterium tuberculosis | Hypothetical protein | 0.0037 | 1 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0 | 0.5 |
Trichomonas vaginalis | peptide N-glycanase, putative | 0.0037 | 1 | 1 |
Mycobacterium leprae | Conserved hypothetical protein | 0.0037 | 1 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.0037 | 1 | 1 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0 | 0.5 |
Giardia lamblia | Transglutaminase/protease, putative | 0.0037 | 1 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0 | 0.5 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0 | 0.5 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0037 | 1 | 1 |
Onchocerca volvulus | 0.0037 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.