Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium vivax | vivapain-2 | 0.01 | 0 | 0.5 |
Plasmodium falciparum | cysteine proteinase falcipain 3 | 0.01 | 0 | 0.5 |
Loa Loa (eye worm) | cathepsin B | 0.0157 | 0.0661 | 0.0661 |
Brugia malayi | hypothetical protein | 0.0104 | 0.0046 | 0.0046 |
Echinococcus multilocularis | cathepsin b | 0.0426 | 0.3783 | 0.8278 |
Toxoplasma gondii | cathepsin B | 0.0157 | 0.0661 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0157 | 0.0661 | 0.5 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0426 | 0.3783 | 1 |
Trypanosoma brucei | cysteine peptidase C (CPC) | 0.0157 | 0.0661 | 1 |
Trypanosoma cruzi | cysteine peptidase C (CPC), putative | 0.0157 | 0.0661 | 0.1748 |
Giardia lamblia | Cathepsin B precursor | 0.0157 | 0.0661 | 0.5 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0426 | 0.3783 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.01 | 0 | 0.5 |
Echinococcus multilocularis | geminin | 0.0165 | 0.0757 | 0.1657 |
Brugia malayi | cathepsin B-like cysteine proteinase | 0.0426 | 0.3783 | 0.3783 |
Onchocerca volvulus | 0.0309 | 0.2427 | 0.9969 | |
Entamoeba histolytica | cysteine protease, putative | 0.01 | 0 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0757 | 0.2001 |
Echinococcus granulosus | cathepsin b | 0.0426 | 0.3783 | 0.8278 |
Plasmodium falciparum | cysteine proteinase falcipain 2a | 0.01 | 0 | 0.5 |
Echinococcus multilocularis | rho associated protein kinase | 0.0309 | 0.2434 | 0.5326 |
Plasmodium falciparum | cysteine proteinase falcipain 2b | 0.01 | 0 | 0.5 |
Schistosoma mansoni | integrin beta subunit | 0.039 | 0.3367 | 0.89 |
Loa Loa (eye worm) | hypothetical protein | 0.0104 | 0.0046 | 0.0046 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0426 | 0.3783 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.01 | 0 | 0.5 |
Loa Loa (eye worm) | kelch domain-containing protein family protein | 0.0104 | 0.0046 | 0.0046 |
Schistosoma mansoni | hypothetical protein | 0.0165 | 0.0757 | 0.2001 |
Brugia malayi | Kelch motif family protein | 0.0104 | 0.0046 | 0.0046 |
Echinococcus granulosus | rho-associated protein kinase 1 | 0.0309 | 0.2434 | 0.5326 |
Echinococcus granulosus | cathepsin b | 0.0426 | 0.3783 | 0.8278 |
Brugia malayi | Integrin beta pat-3 precursor | 0.067 | 0.6623 | 0.6623 |
Schistosoma mansoni | SmCB2 peptidase (C01 family) | 0.0426 | 0.3783 | 1 |
Echinococcus multilocularis | integrin beta 2 | 0.0493 | 0.4571 | 1 |
Entamoeba histolytica | cysteine proteinase, putative | 0.01 | 0 | 0.5 |
Echinococcus granulosus | integrin beta 2 | 0.0493 | 0.4571 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0426 | 0.3783 | 0.3783 |
Loa Loa (eye worm) | AGC/DMPK/ROCK protein kinase | 0.0961 | 1 | 1 |
Giardia lamblia | Cathepsin B precursor | 0.0157 | 0.0661 | 0.5 |
Loa Loa (eye worm) | integrin beta-2 | 0.067 | 0.6623 | 0.6623 |
Echinococcus granulosus | geminin | 0.0165 | 0.0757 | 0.1657 |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0426 | 0.3783 | 1 |
Schistosoma mansoni | serine/threonine protein kinase | 0.0309 | 0.2434 | 0.6434 |
Echinococcus multilocularis | cathepsin b | 0.0426 | 0.3783 | 0.8278 |
Trichomonas vaginalis | Clan CA, family C1, cathepsin B-like cysteine peptidase | 0.0157 | 0.0661 | 1 |
Plasmodium vivax | vivapain-2 | 0.01 | 0 | 0.5 |
Onchocerca volvulus | 0.0309 | 0.2434 | 1 | |
Schistosoma mansoni | cathepsin B-like peptidase (C01 family) | 0.0157 | 0.0661 | 0.1748 |
Leishmania major | cysteine peptidase C (CPC),CPC cysteine peptidase, Clan CA, family C1, Cathepsin B-like | 0.0157 | 0.0661 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.