Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | mitogen-activated protein kinase 3, putative,map kinase 3, putative | 0.2592 | 0.5815 | 1 |
Schistosoma mansoni | protein kinase | 0.0013 | 0 | 0.5 |
Brugia malayi | P38 map kinase family protein 2 | 0.2592 | 0.5815 | 1 |
Echinococcus granulosus | discoidin domain receptor | 0.0085 | 0.0163 | 0.0281 |
Echinococcus granulosus | mitogen activated protein kinase 11 | 0.2592 | 0.5815 | 1 |
Onchocerca volvulus | 0.0087 | 0.0167 | 0.5 | |
Echinococcus granulosus | mitogen activated protein kinase 14 | 0.2592 | 0.5815 | 1 |
Plasmodium falciparum | protein kinase, putative | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.4448 | 1 | 1 |
Schistosoma mansoni | protein kinase | 0.0013 | 0 | 0.5 |
Schistosoma mansoni | protein kinase | 0.0013 | 0 | 0.5 |
Loa Loa (eye worm) | inward rectifying k channel family protein 1 | 0.4448 | 1 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.2592 | 0.5815 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.4448 | 1 | 1 |
Entamoeba histolytica | protein kinase domain containing protein | 0.0013 | 0 | 0.5 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.2592 | 0.5815 | 1 |
Toxoplasma gondii | hypothetical protein | 0.4448 | 1 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 14 | 0.2592 | 0.5815 | 1 |
Loa Loa (eye worm) | CMGC/MAPK/P38 protein kinase | 0.2592 | 0.5815 | 0.5755 |
Loa Loa (eye worm) | hypothetical protein | 0.0085 | 0.0163 | 0.0021 |
Trypanosoma brucei | mitogen-activated protein kinase 3, putative | 0.2592 | 0.5815 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.2592 | 0.5815 | 1 |
Trypanosoma cruzi | mitogen-activated protein kinase 3, putative | 0.2592 | 0.5815 | 1 |
Echinococcus multilocularis | mitogen activated protein kinase 11 | 0.2592 | 0.5815 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.