Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0276 | 0.2054 | 0.7831 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0098 | 0.0486 | 0.1565 |
Trypanosoma brucei | DNA topoisomerase IA, putative | 0.0098 | 0.0486 | 0.0878 |
Loa Loa (eye worm) | DNA topoisomerase III | 0.0098 | 0.0486 | 0.1565 |
Echinococcus granulosus | DNA topoisomerase 3 beta 1 | 0.0098 | 0.0486 | 0.1565 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0396 | 0.3106 | 0.3106 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.0715 | 0.5919 | 0.5919 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0012 | 0.0038 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0012 | 0.0038 |
Echinococcus granulosus | DNA topoisomerase 3 alpha | 0.0098 | 0.0486 | 0.1565 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0396 | 0.3106 | 0.5247 |
Mycobacterium leprae | Probable DNA topoisomerase I TopA (omega-protein) (relaxing enzyme) (untwisting enzyme) (swivelase) (type I DNA topoisomerase) ( | 0.0098 | 0.0486 | 0.1854 |
Schistosoma mansoni | DNA topoisomerase II | 0.0396 | 0.3106 | 1 |
Leishmania major | DNA topoisomerase III, putative | 0.0098 | 0.0486 | 0.0878 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0098 | 0.0486 | 0.0878 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0396 | 0.3106 | 1 |
Plasmodium falciparum | DNA gyrase subunit A | 0.0715 | 0.5919 | 0.5919 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0098 | 0.0486 | 0.0878 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.0715 | 0.5919 | 1 |
Trypanosoma brucei | DNA topoisomerase II alpha, putative | 0.0297 | 0.224 | 0.4043 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0012 | 0.0038 |
Chlamydia trachomatis | DNA topoisomerase I | 0.0098 | 0.0486 | 0.0486 |
Leishmania major | DNA topoisomerase 1A | 0.0098 | 0.0486 | 0.0878 |
Brugia malayi | DNA topoisomerase III beta-1 | 0.0098 | 0.0486 | 0.1565 |
Plasmodium falciparum | DNA gyrase subunit B | 0.1178 | 1 | 1 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0074 | 0.0274 | 0.0274 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.1178 | 1 | 1 |
Trypanosoma brucei | DNA topoisomerase II beta, putative | 0.0297 | 0.224 | 0.4043 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0098 | 0.0486 | 0.1565 |
Brugia malayi | Probable DNA topoisomerase II | 0.0396 | 0.3106 | 1 |
Schistosoma mansoni | prokaryotic DNA topoisomerase | 0.0098 | 0.0486 | 0.1565 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0396 | 0.3106 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0396 | 0.3106 | 1 |
Leishmania major | DNA topoisomerase ii | 0.0297 | 0.224 | 0.4043 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0274 | 0.0882 |
Plasmodium falciparum | DNA topoisomerase 3, putative | 0.0098 | 0.0486 | 0.0486 |
Mycobacterium ulcerans | DNA topoisomerase I | 0.0098 | 0.0486 | 0.0486 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0297 | 0.224 | 0.4043 |
Wolbachia endosymbiont of Brugia malayi | topoisomerase IA, TopA | 0.0098 | 0.0486 | 0.0486 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0672 | 0.554 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1585 | 0.5105 |
Trypanosoma cruzi | DNA topoisomerase III, putative | 0.0098 | 0.0486 | 0.0878 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.0715 | 0.5919 | 0.5919 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0396 | 0.3106 | 1 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0098 | 0.0486 | 0.1565 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0396 | 0.3106 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.0715 | 0.5919 | 0.5919 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0012 | 0.0038 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0672 | 0.554 | 1 |
Plasmodium vivax | DNA topoisomerase 3, putative | 0.0098 | 0.0486 | 0.0486 |
Trypanosoma cruzi | DNA topoisomerase II, putative | 0.0297 | 0.224 | 0.4043 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0598 | 0.4886 | 0.8254 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0098 | 0.0486 | 0.0878 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0012 | 0.0038 |
Entamoeba histolytica | DNA topoisomerase III, putative | 0.0098 | 0.0486 | 0.1565 |
Trypanosoma brucei | DNA topoisomerase III, putative | 0.0098 | 0.0486 | 0.0878 |
Toxoplasma gondii | DNA topoisomerase domain-containing protein | 0.0098 | 0.0486 | 0.0821 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0396 | 0.3106 | 1 |
Echinococcus multilocularis | rho GTPase activating protein 20 | 0.0098 | 0.0486 | 0.1565 |
Toxoplasma gondii | DNA topoisomerase family protein | 0.0098 | 0.0486 | 0.0821 |
Trichomonas vaginalis | prokaryotic DNA topoisomerase, putative | 0.0098 | 0.0486 | 0.1565 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0902 | 0.7566 | 0.7566 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0396 | 0.3106 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0672 | 0.554 | 1 |
Loa Loa (eye worm) | DNA topoisomerase III beta-1 | 0.0098 | 0.0486 | 0.1565 |
Giardia lamblia | DNA topoisomerase III | 0.0098 | 0.0486 | 0.1784 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0012 | 0.0038 |
Chlamydia trachomatis | DNA gyrase subunit A | 0.0715 | 0.5919 | 0.5919 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.0715 | 0.5919 | 0.5919 |
Giardia lamblia | DNA topoisomerase III | 0.0098 | 0.0486 | 0.1784 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0396 | 0.3106 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0672 | 0.554 | 1 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.1178 | 1 | 1 |
Leishmania major | DNA topoisomerase III, putative | 0.0098 | 0.0486 | 0.0878 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.1178 | 1 | 1 |
Echinococcus multilocularis | DNA topoisomerase 3 beta 1 | 0.0098 | 0.0486 | 0.1565 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0715 | 0.5919 | 0.5919 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0098 | 0.0486 | 0.0878 |
Loa Loa (eye worm) | hypothetical protein | 0.0074 | 0.0274 | 0.0882 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0396 | 0.3106 | 1 |
Trypanosoma cruzi | DNA topoisomerase IA, putative | 0.0098 | 0.0486 | 0.0878 |
Brugia malayi | GRF zinc finger family protein | 0.0098 | 0.0486 | 0.1565 |
Treponema pallidum | DNA topoisomerase I (topA) | 0.0098 | 0.0486 | 0.0486 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0224 | 0.1591 | 0.1591 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0396 | 0.3106 | 0.3106 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0012 | 0.0038 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0396 | 0.3106 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.1178 | 1 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0012 | 0.0038 |
Giardia lamblia | DNA topoisomerase II | 0.0353 | 0.2726 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0223 | 0.1585 | 0.5105 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.1178 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0012 | 0.0038 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0341 | 0.2623 | 1 |
Brugia malayi | DNA topoisomerase III | 0.0098 | 0.0486 | 0.1565 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.