Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | Isocitrate dehydrogenase [NAD] subunit gamma mitochondrial | 0.0033 | 0.0002 | 0.0133 |
Entamoeba histolytica | tartrate dehydrogenase, putative | 0.0033 | 0.0002 | 0.5 |
Plasmodium vivax | isocitrate dehydrogenase [NADP], mitochondrial, putative | 0.0275 | 0.0141 | 0.5 |
Schistosoma mansoni | NADP-specific isocitrate dehydrogenase | 0.0275 | 0.0141 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0275 | 0.0141 | 0.5 |
Trypanosoma cruzi | isocitrate dehydrogenase, putative | 0.0275 | 0.0141 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase | 0.0275 | 0.0141 | 1 |
Mycobacterium tuberculosis | Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) | 0.0275 | 0.0141 | 0.0139 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0275 | 0.0141 | 0.5 |
Echinococcus multilocularis | isocitrate dehydrogenase 2 (NADP+) | 0.0275 | 0.0141 | 1 |
Trypanosoma cruzi | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0275 | 0.0141 | 0.5 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0275 | 0.0141 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0275 | 0.0141 | 1 |
Brugia malayi | Isocitrate dehydrogenase | 0.0275 | 0.0141 | 1 |
Echinococcus multilocularis | NADP dependent isocitrate dehydrogenase | 0.0275 | 0.0141 | 1 |
Toxoplasma gondii | isocitrate dehydrogenase | 0.0275 | 0.0141 | 0.5 |
Echinococcus granulosus | NADP dependent isocitrate dehydrogenase | 0.0275 | 0.0141 | 1 |
Schistosoma mansoni | unc-13 (munc13) | 0.0033 | 0.0002 | 0.0133 |
Plasmodium falciparum | isocitrate dehydrogenase [NADP], mitochondrial | 0.0275 | 0.0141 | 0.5 |
Leishmania major | isocitrate dehydrogenase [NADP], mitochondrial precursor, putative | 0.0275 | 0.0141 | 1 |
Trichomonas vaginalis | isocitrate dehydrogenase, putative | 0.0033 | 0.0002 | 0.5 |
Brugia malayi | isocitrate dehydrogenase | 0.0275 | 0.0141 | 1 |
Mycobacterium ulcerans | histidinol dehydrogenase | 1.7357 | 1 | 1 |
Mycobacterium tuberculosis | Probable histidinol dehydrogenase HisD (HDH) | 1.7357 | 1 | 1 |
Trypanosoma brucei | isocitrate dehydrogenase, putative | 0.0275 | 0.0141 | 0.5 |
Loa Loa (eye worm) | isocitrate dehydrogenase | 0.0275 | 0.0141 | 1 |
Schistosoma mansoni | isocitrate dehydrogenase | 0.0033 | 0.0002 | 0.0133 |
Wolbachia endosymbiont of Brugia malayi | isocitrate dehydrogenase | 0.0033 | 0.0002 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.