Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | glutamate NMDA receptor subunit | 0.0483 | 0.6185 | 0.8753 |
Trichomonas vaginalis | set domain proteins, putative | 0.0233 | 0.2243 | 0.5 |
Schistosoma mansoni | ATP-binding cassette transporter | 0.0208 | 0.1853 | 0.2996 |
Echinococcus multilocularis | glutamate receptor NMDA | 0.0237 | 0.2305 | 0.3262 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0384 | 0.4626 | 0.6547 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0208 | 0.1853 | 0.2996 |
Brugia malayi | Glutamate receptor 1 precursor | 0.0208 | 0.1853 | 0.1845 |
Echinococcus multilocularis | tm gpcr rhodopsin gpcr rhodopsin superfamily | 0.0539 | 0.7066 | 1 |
Schistosoma mansoni | glutamate receptor kainate | 0.0208 | 0.1853 | 0.2996 |
Echinococcus granulosus | glutamate receptor NMDA | 0.0237 | 0.2305 | 0.3262 |
Schistosoma mansoni | glutamate receptor AMPA | 0.0208 | 0.1853 | 0.2996 |
Schistosoma mansoni | lysosomal Pro-Xaa carboxypeptidase (S28 family) | 0.0092 | 0.001 | 0.0016 |
Echinococcus granulosus | nmda type glutamate receptor | 0.0271 | 0.2843 | 0.4024 |
Loa Loa (eye worm) | glutamate receptor 2 | 0.0208 | 0.1853 | 0.1845 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0243 | 0.2392 | 0.3385 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0205 | 0.1797 | 0.1789 |
Loa Loa (eye worm) | hypothetical protein | 0.0429 | 0.5329 | 0.5324 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0243 | 0.2392 | 0.3385 |
Echinococcus granulosus | glutamate receptor 2 | 0.0152 | 0.0957 | 0.1354 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0243 | 0.2392 | 0.3385 |
Echinococcus multilocularis | Lysosomal Pro X carboxypeptidase | 0.0092 | 0.001 | 0.0014 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0271 | 0.2843 | 0.4024 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0243 | 0.2392 | 0.3385 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 3 | 0.0147 | 0.0887 | 0.1255 |
Echinococcus granulosus | tm gpcr rhodopsin | 0.0539 | 0.7066 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0205 | 0.1797 | 0.1789 |
Loa Loa (eye worm) | hypothetical protein | 0.0725 | 1 | 1 |
Schistosoma mansoni | glutamate receptor NMDA | 0.0483 | 0.6185 | 1 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.0725 | 1 | 0.5 |
Schistosoma mansoni | glutamate receptor NMDA | 0.048 | 0.6131 | 0.9912 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0243 | 0.2392 | 0.3385 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0208 | 0.1853 | 0.2623 |
Echinococcus granulosus | Glutamate receptor ionotropic kainate 2 | 0.0243 | 0.2392 | 0.3385 |
Echinococcus multilocularis | glutamate receptor 2 | 0.0152 | 0.0957 | 0.1354 |
Schistosoma mansoni | glutamate receptor kainate | 0.0208 | 0.1853 | 0.2996 |
Schistosoma mansoni | glutamate receptor kainate | 0.0208 | 0.1853 | 0.2996 |
Echinococcus multilocularis | nmda type glutamate receptor | 0.0384 | 0.4626 | 0.6547 |
Brugia malayi | Glutamate receptor 2 precursor | 0.0208 | 0.1853 | 0.1845 |
Echinococcus granulosus | glutamate receptor 2 | 0.0243 | 0.2392 | 0.3385 |
Echinococcus multilocularis | glutamate receptor, ionotrophic, AMPA 3 | 0.0243 | 0.2392 | 0.3385 |
Echinococcus granulosus | Lysosomal Pro X carboxypeptidase | 0.0092 | 0.001 | 0.0014 |
Onchocerca volvulus | 0.0233 | 0.2243 | 0.5 | |
Loa Loa (eye worm) | hypothetical protein | 0.0371 | 0.441 | 0.4404 |
Echinococcus multilocularis | Glutamate receptor, ionotropic kainate 2 | 0.0243 | 0.2392 | 0.3385 |
Echinococcus granulosus | glutamate receptor ionotrophic AMPA 3 | 0.0243 | 0.2392 | 0.3385 |
Echinococcus multilocularis | glutamate (NMDA) receptor subunit | 0.0483 | 0.6185 | 0.8753 |
Leishmania major | C-8 sterol isomerase-like protein | 0.0725 | 1 | 0.5 |
Loa Loa (eye worm) | glutamate receptor 1 | 0.0208 | 0.1853 | 0.1845 |
Loa Loa (eye worm) | hypothetical protein | 0.0429 | 0.5329 | 0.5324 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.0725 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.