Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Leishmania major | C-8 sterol isomerase-like protein | 0.1853 | 0.8454 | 0.5 |
Echinococcus multilocularis | vesicular acetylcholine transporter | 0.2019 | 1 | 0.5 |
Trypanosoma brucei | C-8 sterol isomerase, putative | 0.1853 | 0.8454 | 0.5 |
Echinococcus granulosus | vesicular acetylcholine transporter | 0.2019 | 1 | 0.5 |
Loa Loa (eye worm) | vesicular acetylcholine transporter unc-17 | 0.2019 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1853 | 0.8454 | 0.8454 |
Schistosoma mansoni | vesicular acetylcholine transporter | 0.2019 | 1 | 0.5 |
Trypanosoma cruzi | C-8 sterol isomerase, putative | 0.1853 | 0.8454 | 0.5 |
Onchocerca volvulus | Vesicular acetylcholine transporter homolog | 0.2019 | 1 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.