Detailed information for compound 824200

Basic information

Technical information
  • TDR Targets ID: 824200
  • Name: N-(4-ethoxyphenyl)-N-[(6-methoxy-2-oxo-1H-qui nolin-3-yl)methyl]benzenesulfonamide
  • MW: 464.533 | Formula: C25H24N2O5S
  • H donors: 1 H acceptors: 4 LogP: 4.68 Rotable bonds: 8
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)N(S(=O)(=O)c1ccccc1)Cc1cc2cc(OC)ccc2nc1O
  • InChi: 1S/C25H24N2O5S/c1-3-32-21-11-9-20(10-12-21)27(33(29,30)23-7-5-4-6-8-23)17-19-15-18-16-22(31-2)13-14-24(18)26-25(19)28/h4-16H,3,17H2,1-2H3,(H,26,28)
  • InChiKey: OPHDCQCHEPUEJO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-ethoxyphenyl)-N-[(2-keto-6-methoxy-1H-quinolin-3-yl)methyl]benzenesulfonamide
  • T5329238
  • ZINC02210768

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0383 0.8988 1
Loa Loa (eye worm) hypothetical protein 0.0076 0.0336 0.038
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0174 0.3102 1
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.015 0.2408 0.7665
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.1782 0.3572
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0167 0.2882 0.5955
Entamoeba histolytica Phosphatidylinositol 3- and 4-kinase family 0.0126 0.173 0.3459
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.015 0.2408 0.2569
Entamoeba histolytica hypothetical protein 0.019 0.3532 0.7362
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit alpha, beta, delta, putative 0.0092 0.0782 0.1405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0099 0.0961 0.1794
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0158 0.2649 0.2841
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.015 0.2408 0.2306
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.1505 0.2972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.206 0.4175
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0233 0.4749 1
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0092 0.0782 0.1405
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.1783 0.3574
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0233 0.4749 1
Trypanosoma cruzi target of rapamycin kinase 3 0.014 0.2131 0.2372
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0092 0.0782 0.0657
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.1853 0.3727
Loa Loa (eye worm) CAMK/CAMKL/CHK1 protein kinase 0.0378 0.8851 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0383 0.8988 1
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0233 0.4749 0.5213
Brugia malayi Protein kinase domain containing protein 0.0378 0.8851 0.9846
Brugia malayi phosphoinositide 3'-hydroxykinase p110-alpha subunit, putative 0.0186 0.3433 0.3727
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.015 0.2408 0.2306
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0383 0.8988 0.8974
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.1782 0.3572
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0688 0.1202
Trypanosoma brucei target of rapamycin kinase 3, putative 0.014 0.2131 0.6732
Trypanosoma cruzi phosphatidylinositol 3-kinase, putative 0.0069 0.0133 0.0148
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.1783 0.3574
Trichomonas vaginalis PIKK family atypical protein kinase 0.013 0.1853 0.3727
Schistosoma mansoni serine/threonine protein kinase 0.0378 0.8851 0.8836
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0233 0.4749 0.5284
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0383 0.8988 1
Echinococcus granulosus phosphatidylinositol 4 phosphate 3 kinase C2 0.0158 0.2649 0.2549
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.015 0.2408 0.7665
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.015 0.2408 0.268
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.206 0.4175
Trichomonas vaginalis PIKK family atypical protein kinase 0.015 0.2408 0.4929
Echinococcus multilocularis phosphatidylinositol 4 phosphate 3 kinase C2 0.0158 0.2649 0.2549
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0174 0.3102 1
Trichomonas vaginalis phosphatidylinositol kinase, putative 0.0092 0.0782 0.1405
Trichomonas vaginalis PIKK family atypical protein kinase 0.015 0.2408 0.4929
Trichomonas vaginalis phopsphatidylinositol 3-kinase, drosophila, putative 0.0233 0.4749 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.206 0.4175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0688 0.1202
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.1783 0.3574
Giardia lamblia GTOR 0.015 0.2408 1
Toxoplasma gondii non-specific serine/threonine protein kinase 0.0076 0.0336 0.1052
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.1505 0.2972
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.206 0.4175
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.014 0.2131 0.3923
Loa Loa (eye worm) phosphatidylinositol 3 0.0376 0.8782 0.9922
Trichomonas vaginalis PIKK family atypical protein kinase 0.0126 0.173 0.3459
Loa Loa (eye worm) phosphatidylinositol 3 0.0174 0.3102 0.3504
Trichomonas vaginalis PIKK family atypical protein kinase 0.0089 0.0688 0.1202
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0383 0.8988 0.8974
Toxoplasma gondii target of rapamycin (TOR), putative 0.0137 0.206 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.213 0.4327
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0092 0.0782 0.0732
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.213 0.4327
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.1782 0.3572
Schistosoma mansoni phosphatidylinositol-45-bisphosphate 3-kinase catalytic subunit alpha PI3K 0.0419 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.206 0.4175
Trichomonas vaginalis PIKK family atypical protein kinase 0.0128 0.1783 0.3574
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0092 0.0782 0.1405
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.015 0.2408 0.4929
Trypanosoma cruzi phosphatidylinositol 3-kinase 2, putative 0.0233 0.4749 0.5284
Echinococcus multilocularis phosphatidylinositol 4,5 bisphosphate 3 kinase 0.0419 1 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.1505 0.2972
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.015 0.2408 0.4929
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.206 0.4175
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.213 0.4327
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.213 0.4327
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0115 0.1431 0.2812
Trichomonas vaginalis conserved hypothetical protein 0.0076 0.0336 0.0439
Trichomonas vaginalis PIKK family atypical protein kinase 0.014 0.213 0.4327
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0118 0.1505 0.4622
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.015 0.2408 0.2306
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.015 0.2408 0.5658
Trichomonas vaginalis PIKK family atypical protein kinase 0.0137 0.206 0.4175
Loa Loa (eye worm) phosphatidylinositol 3 0.015 0.2408 0.2721
Trichomonas vaginalis PIKK family atypical protein kinase 0.0174 0.3102 0.6431
Entamoeba histolytica phosphatidylinositol 3-kinase 1, putative 0.0205 0.3967 0.8306
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0086 0.0614 0.162
Trichomonas vaginalis PIKK family atypical protein kinase 0.0091 0.0759 0.1355
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0383 0.8988 0.8974
Trichomonas vaginalis PIKK family atypical protein kinase 0.015 0.2408 0.4929
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.015 0.2408 0.268
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.0092 0.0782 0.1405
Entamoeba histolytica phosphatidylinositol 3-kinase, putative 0.019 0.3532 0.7362
Loa Loa (eye worm) hypothetical protein 0.0069 0.0133 0.0151
Trypanosoma cruzi phosphatidylinositol 3-kinase vps34-like 0.0092 0.0782 0.087
Giardia lamblia Phosphoinositide-3-kinase, catalytic, alpha polypeptide 0.0123 0.1665 0.6659
Trichomonas vaginalis PIKK family atypical protein kinase 0.0118 0.1505 0.2972
Trichomonas vaginalis phosphatidylinositol 3-kinase class, putative 0.0167 0.2882 0.5955
Trichomonas vaginalis phosphatidylinositol 3-kinase catalytic subunit gamma, putative 0.0233 0.4749 1
Loa Loa (eye worm) hypothetical protein 0.0074 0.0283 0.0319
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0069 0.0133 0.0148
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.015 0.2408 0.5658
Loa Loa (eye worm) hypothetical protein 0.0158 0.2649 0.2993
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0092 0.0782 0.2185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0101 0.1037 0.1957

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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