Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0094 | 0.1562 | 0.5 |
Brugia malayi | Animal haem peroxidase family protein | 0.0243 | 0.5627 | 1 |
Schistosoma mansoni | peroxidasin | 0.0243 | 0.5627 | 1 |
Brugia malayi | Peroxidasin | 0.0243 | 0.5627 | 1 |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0403 | 1 | 1 |
Schistosoma mansoni | peroxidasin | 0.0243 | 0.5627 | 1 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase, topoisomerase II, B subunit, GyrB | 0.0403 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Onchocerca volvulus | Peroxidasin homolog | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0094 | 0.1562 | 0.2777 |
Brugia malayi | Probable DNA topoisomerase II | 0.0094 | 0.1562 | 0.2777 |
Giardia lamblia | DNA topoisomerase II | 0.0082 | 0.1217 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0094 | 0.1562 | 0.2777 |
Treponema pallidum | DNA gyrase, subunit B (gyrB) | 0.0403 | 1 | 0.5 |
Echinococcus granulosus | biogenic amine 5HT receptor | 0.0128 | 0.2487 | 0.442 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit B | 0.0403 | 1 | 0.5 |
Echinococcus multilocularis | peroxidasin | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0233 | 0.5353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0243 | 0.5627 | 1 |
Mycobacterium leprae | Probable DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0139 | 0.278 | 0.5 |
Onchocerca volvulus | Peroxidase homolog | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0243 | 0.5627 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0233 | 0.5353 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0128 | 0.2487 | 0.442 |
Schistosoma mansoni | DNA topoisomerase II | 0.0094 | 0.1562 | 0.2777 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0233 | 0.5353 | 1 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0243 | 0.5627 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0233 | 0.5353 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0775 | 0.1378 |
Onchocerca volvulus | Peroxidasin homolog | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Onchocerca volvulus | Dual oxidase homolog | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Echinococcus granulosus | peroxidasin | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0094 | 0.1562 | 0.2777 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Onchocerca volvulus | 0.0243 | 0.5627 | 1 | |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0233 | 0.5353 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0094 | 0.1562 | 0.5 |
Onchocerca volvulus | 0.0243 | 0.5627 | 1 | |
Onchocerca volvulus | 0.0243 | 0.5627 | 1 | |
Onchocerca volvulus | Peroxidase homolog | 0.0243 | 0.5627 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0243 | 0.5627 | 1 |
Brugia malayi | Animal haem peroxidase family protein | 0.0243 | 0.5627 | 1 |
Echinococcus multilocularis | serotonin receptor | 0.0128 | 0.2487 | 0.442 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0094 | 0.1562 | 0.2777 |
Brugia malayi | Animal haem peroxidase family protein | 0.0243 | 0.5627 | 1 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0403 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.2487 | 0.442 |
Mycobacterium tuberculosis | DNA gyrase (subunit B) GyrB (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.0403 | 1 | 0.5 |
Schistosoma mansoni | biogenic amine (5HT) receptor | 0.0128 | 0.2487 | 0.442 |
Brugia malayi | Blistered cuticle protein 3 | 0.0243 | 0.5627 | 1 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0094 | 0.1562 | 0.2777 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0094 | 0.1562 | 0.2919 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0094 | 0.1562 | 0.2777 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Onchocerca volvulus | Chorion peroxidase homolog | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0094 | 0.1562 | 0.2777 |
Loa Loa (eye worm) | animal heme peroxidase | 0.0243 | 0.5627 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0094 | 0.1562 | 0.2777 |
Loa Loa (eye worm) | blistered cuticle protein 3 | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0128 | 0.2487 | 0.442 |
Brugia malayi | hypothetical protein | 0.0243 | 0.5627 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0775 | 0.1378 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.