Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | metallo-peptidase, Clan MF, Family M17 | 0.1316 | 0 | 0.5 |
Leishmania major | cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 | 0.1316 | 0 | 0.5 |
Plasmodium vivax | M17 leucyl aminopeptidase, putative | 0.147 | 0.1478 | 0.5 |
Toxoplasma gondii | leucyl aminopeptidase LAP | 0.147 | 0.1478 | 0.5 |
Trypanosoma cruzi | metallo-peptidase, Clan MF, Family M17, putative | 0.1316 | 0 | 0.5 |
Echinococcus multilocularis | aminopeptidase N | 0.2356 | 1 | 1 |
Chlamydia trachomatis | cytosol aminopeptidase | 0.147 | 0.1478 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2028 | 0.6852 | 1 |
Mycobacterium tuberculosis | Probable aminopeptidase PepB | 0.147 | 0.1478 | 0.5 |
Echinococcus granulosus | aminopeptidase N | 0.2356 | 1 | 1 |
Onchocerca volvulus | 0.2356 | 1 | 0.5 | |
Wolbachia endosymbiont of Brugia malayi | leucyl aminopeptidase | 0.147 | 0.1478 | 0.5 |
Trypanosoma cruzi | cytosolic leucyl aminopeptidase, putative | 0.1316 | 0 | 0.5 |
Mycobacterium leprae | Probable cytosol aminopeptidase PepB | 0.147 | 0.1478 | 0.5 |
Loa Loa (eye worm) | peptidase family M1 containing protein | 0.1752 | 0.4195 | 0.5422 |
Plasmodium falciparum | M17 leucyl aminopeptidase | 0.1316 | 0 | 0.5 |
Mycobacterium ulcerans | leucyl aminopeptidase | 0.147 | 0.1478 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.