TDR Targets

Basic information

Technical information

TDR Targets ID: 825370
Name: methyl 4-[(4-chlorophenyl)sulfonylmethyl]-6-( 4-hydroxyphenyl)-2-oxo-3,6-dihydro-1H-pyrimid ine-5-carboxylate
MW: 436.866 | Formula: C19H17ClN2O6S
H donors: 3 H acceptors: 5 LogP: 1.65 Rotable bonds: 6
Rule of 5 violations (Lipinski): 1
SMILES: COC(=O)C1=C(NC(=O)NC1c1ccc(cc1)O)CS(=O)(=O)c1ccc(cc1)Cl
InChi: 1S/C19H17ClN2O6S/c1-28-18(24)16-15(10-29(26,27)14-8-4-12(20)5-9-14)21-19(25)22-17(16)11-2-6-13(23)7-3-11/h2-9,17,23H,10H2,1H3,(H2,21,22,25)
InChiKey: XMUZTWFKYDHEIV-UHFFFAOYSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

4-[(4-chlorophenyl)sulfonylmethyl]-6-(4-hydroxyphenyl)-2-oxo-3,6-dihydro-1H-pyrimidine-5-carboxylic acid methyl ester
4-[(4-chlorophenyl)sulfonylmethyl]-6-(4-hydroxyphenyl)-2-keto-3,6-dihydro-1H-pyrimidine-5-carboxylic acid methyl ester

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	GNAS complex locus	Starlite/ChEMBL	No references

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Brugia malayi	GTP-binding regulatory protein Gs alpha-S chain, putative	Get druggable targets OG5_131088	All targets in OG5_131088
Echinococcus granulosus	guanine nucleotide binding protein Gs subunit	Get druggable targets OG5_131088	All targets in OG5_131088
Loa Loa (eye worm)	GTP-binding regulatory protein Gs alpha-S chain	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma mansoni	Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein)	Get druggable targets OG5_131088	All targets in OG5_131088
Schistosoma japonicum	ko:K04632 guanine nucleotide binding protein (G protein), alpha stimulating, putative	Get druggable targets OG5_131088	All targets in OG5_131088

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Schistosoma mansoni	GTP-binding protein alpha subunit gna	GNAS complex locus	394 aa	450 aa	28.7 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.8653	1
Brugia malayi	ORL1-like opioid receptor	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	amine GPCR	0.0097	0.8653	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.8653	0.8653
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Brugia malayi	Serotonin receptor	0.0097	0.8653	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0097	0.8653	0.7937
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.8653	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0097	0.8653	0.7937
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Brugia malayi	Serotonin/octopamine receptor family protein 7	0.0097	0.8653	1
Schistosoma mansoni	peptide (allatostatin)-like receptor	0.0097	0.8653	1
Brugia malayi	hypothetical protein	0.0097	0.8653	1
Brugia malayi	larval opioid receptor	0.0097	0.8653	1
Echinococcus multilocularis	neuropeptides capa receptor	0.0097	0.8653	0.8653
Schistosoma mansoni	growth hormone secretagogue receptor	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	amine GPCR	0.0097	0.8653	1
Onchocerca volvulus		0.0097	0.8653	0.5
Echinococcus multilocularis	neuropeptide Y receptor	0.0097	0.8653	0.8653
Schistosoma mansoni	adenoreceptor	0.0097	0.8653	1
Loa Loa (eye worm)	melatonin receptor type 1A	0.0097	0.8653	1
Brugia malayi	RE15519p	0.0097	0.8653	1
Schistosoma mansoni	amine GPCR	0.0097	0.8653	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.8653	1
Brugia malayi	Serotonin receptor	0.0097	0.8653	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.8653	0.8653
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.8653	0.7937
Loa Loa (eye worm)	TYRA-2 protein	0.0097	0.8653	1
Brugia malayi	Dopamine receptor protein 2	0.0097	0.8653	1
Echinococcus granulosus	7tm_1 domain containing protein	0.0097	0.8653	0.7937
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	alpha 1A adrenergic receptor	0.0097	0.8653	0.8653
Echinococcus multilocularis	sex peptide receptor	0.0097	0.8653	0.8653
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	thyrotropin-releasing hormone receptor	0.0097	0.8653	1
Echinococcus granulosus	g protein coupled receptor	0.0097	0.8653	0.7937
Echinococcus multilocularis	g-protein coupled receptor	0.0097	0.8653	0.8653
Brugia malayi	putative neuropeptide receptor	0.0097	0.8653	1
Onchocerca volvulus		0.0097	0.8653	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Onchocerca volvulus		0.0097	0.8653	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.8653	0.7937
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Brugia malayi	G-protein coupled receptor	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	glutamate receptor NMDA	0.0092	0.8069	0.8873
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0097	0.8653	0.8653
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.8653	1
Echinococcus multilocularis	orexin receptor type 2	0.0097	0.8653	0.8653
Echinococcus granulosus	orexin receptor type 2	0.0097	0.8653	0.7937
Echinococcus granulosus	dro:myosuppressin receptor	0.0097	0.8653	0.7937
Echinococcus multilocularis	neuropeptide receptor	0.0097	0.8653	0.8653
Schistosoma mansoni	neuropeptide receptor	0.0097	0.8653	1
Echinococcus multilocularis	serotonin receptor	0.0097	0.8653	0.8653
Brugia malayi	G-protein-linked acetylcholine receptor protein 2, putative	0.0097	0.8653	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.8653	1
Schistosoma mansoni	biogenic amine receptor	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.8653	0.8653
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.8653	0.7937
Echinococcus multilocularis	peptide (allatostatin:somatostatin)	0.0097	0.8653	0.8653
Schistosoma mansoni	biogenic amine receptor	0.0097	0.8653	1
Schistosoma mansoni	neuropeptide f receptor 76f	0.0097	0.8653	1
Onchocerca volvulus		0.0097	0.8653	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Brugia malayi	Dopamine receptor protein 1, putative (partial)	0.0097	0.8653	1
Schistosoma mansoni	hypothetical protein	0.0097	0.8653	1
Onchocerca volvulus		0.0097	0.8653	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.3471	0.3471
Echinococcus granulosus	neuropeptide receptor	0.0097	0.8653	0.7937
Echinococcus multilocularis	somatostatin receptor	0.0097	0.8653	0.8653
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0097	0.8653	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.8653	0.7937
Echinococcus multilocularis	tachykinin peptides receptor 99D	0.0097	0.8653	0.8653
Onchocerca volvulus		0.0097	0.8653	0.5
Echinococcus multilocularis	nmda type glutamate receptor	0.0108	1	1
Echinococcus multilocularis	fmrfamide receptor	0.0097	0.8653	0.8653
Schistosoma mansoni	peptide (allatostatin/somatostatin)-like receptor	0.0097	0.8653	1
Brugia malayi	Unidentified vitellogenin-linked transcript protein 6, putative	0.0097	0.8653	1
Brugia malayi	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	ancient conserved domain protein 2 (cyclin m2)	0.0097	0.8653	1
Schistosoma mansoni	neuropeptide receptor	0.0097	0.8653	1
Schistosoma mansoni	muscarinic acetylcholine (GAR) receptor	0.0097	0.8653	1
Brugia malayi	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	histamine-responsive GPCR (AAF21638)	0.0097	0.8653	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.8653	1
Echinococcus granulosus	nmda type glutamate receptor	0.0085	0.7127	0.56
Brugia malayi	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	biogenic amine (octopamine/dopamine) receptor	0.0097	0.8653	1
Brugia malayi	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.8653	0.8653
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus granulosus	g protein coupled receptor	0.0097	0.8653	0.7937
Onchocerca volvulus		0.0097	0.8653	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus granulosus	biogenic amine 5HT receptor	0.0097	0.8653	0.7937
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0097	0.8653	1
Echinococcus multilocularis	neuropeptide receptor	0.0097	0.8653	0.8653
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.8653	0.8653
Schistosoma mansoni	opsin-like receptor	0.0097	0.8653	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.8653	0.8653
Echinococcus multilocularis	G-protein coupled receptor, putative	0.0097	0.8653	0.8653
Echinococcus granulosus	neuropeptide FF receptor 2	0.0097	0.8653	0.7937
Echinococcus granulosus	neuropeptides capa receptor	0.0097	0.8653	0.7937
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Brugia malayi	G protein-coupled receptor	0.0097	0.8653	1
Onchocerca volvulus		0.0097	0.8653	0.5
Echinococcus granulosus	g-protein coupled receptor	0.0097	0.8653	0.7937
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Brugia malayi	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus granulosus	glutamate receptor NMDA	0.0081	0.6645	0.486
Onchocerca volvulus		0.0097	0.8653	0.5
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.8653	0.7937
Echinococcus granulosus	neuropeptide receptor A26	0.0097	0.8653	0.7937
Echinococcus granulosus	7TM GPCR rhodopsin	0.0097	0.8653	0.7937
Echinococcus multilocularis	G protein coupled 5 hydroxytryptamine receptor	0.0097	0.8653	0.8653
Echinococcus multilocularis	neuropeptide Y receptor	0.0097	0.8653	0.8653
Echinococcus granulosus	G protein coupled receptor 139	0.0097	0.8653	0.7937
Echinococcus multilocularis	neuropeptides capa receptor	0.0097	0.8653	0.8653
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.8653	0.8653
Onchocerca volvulus		0.0097	0.8653	0.5
Brugia malayi	Melatonin receptor type 1A	0.0097	0.8653	1
Brugia malayi	hypothetical protein	0.0097	0.8653	1
Echinococcus granulosus	neuropeptide Y receptor	0.0097	0.8653	0.7937
Echinococcus granulosus	allatostatin A receptor	0.0097	0.8653	0.7937
Echinococcus granulosus	serotonin receptor	0.0097	0.8653	0.7937
Echinococcus multilocularis	biogenic amine (5HT) receptor	0.0097	0.8653	0.8653
Loa Loa (eye worm)	5-hydroxytryptamine 2C receptor	0.0097	0.8653	1
Echinococcus granulosus	neuropeptide receptor	0.0097	0.8653	0.7937
Brugia malayi	Dopamine receptor protein 1	0.0097	0.8653	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.8653	0.8653
Schistosoma mansoni	neuropeptide receptor	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Onchocerca volvulus		0.0097	0.8653	0.5
Echinococcus multilocularis	g protein linked acetylcholine receptor gar 2a	0.0097	0.8653	0.8653
Schistosoma mansoni	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	myosin xvIII	0.0097	0.8653	1
Echinococcus multilocularis	dro:myosuppressin receptor	0.0097	0.8653	0.8653
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.8653	1
Echinococcus granulosus	neuropeptide Y receptor	0.0097	0.8653	0.7937
Echinococcus granulosus	G protein coupled 5 hydroxytryptamine receptor	0.0097	0.8653	0.7937
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.8653	0.7937
Echinococcus multilocularis	neuropeptide FF receptor 2	0.0097	0.8653	0.8653
Echinococcus multilocularis	allatostatin A receptor	0.0097	0.8653	0.8653
Echinococcus multilocularis	fmrfamide receptor	0.0097	0.8653	0.8653
Schistosoma mansoni	opsin-like receptor	0.0097	0.8653	1
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.8653	0.7937
Echinococcus granulosus	tachykinin peptides receptor 99D	0.0097	0.8653	0.7937
Schistosoma mansoni	biogenic amine (dopamine) receptor	0.0097	0.8653	1
Echinococcus granulosus	hypothetical protein	0.0097	0.8653	0.7937
Echinococcus multilocularis	nmda type glutamate receptor	0.0085	0.7127	0.7127
Brugia malayi	GnHR receptor homolog	0.0097	0.8653	1
Echinococcus granulosus	peptide allatostatin:somatostatin	0.0097	0.8653	0.7937
Brugia malayi	neuropeptide F receptor	0.0097	0.8653	1
Brugia malayi	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0097	0.8653	1
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.8653	0.8653
Brugia malayi	AKH receptor	0.0097	0.8653	1
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.8653	0.8653
Echinococcus multilocularis	rhodopsin orphan GPCR	0.0097	0.8653	0.8653
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.8653	1
Echinococcus granulosus	neuropeptide s receptor	0.0097	0.8653	0.7937
Brugia malayi	G protein-coupled receptor F59B2.13	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	glutamate receptor NMDA	0.0081	0.6645	0.6645
Schistosoma mansoni	neuropeptide F-like receptor	0.0097	0.8653	1
Echinococcus granulosus	tm gpcr rhodopsin	0.0097	0.8653	0.7937
Onchocerca volvulus		0.0097	0.8653	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.8653	0.8653
Echinococcus granulosus	sex peptide receptor	0.0097	0.8653	0.7937
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	g protein coupled receptor	0.0097	0.8653	0.8653
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Onchocerca volvulus		0.0097	0.8653	0.5
Onchocerca volvulus	Neuropeptide F receptor homolog	0.0097	0.8653	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.8653	0.7937
Schistosoma mansoni	amine GPCR	0.0097	0.8653	1
Schistosoma mansoni	biogenic amine receptor	0.0097	0.8653	1
Echinococcus granulosus	g protein coupled receptor	0.0097	0.8653	0.7937
Brugia malayi	putative neuropeptide receptor NPR1	0.0097	0.8653	1
Brugia malayi	gonadotropin-releasing hormone receptor 2	0.0097	0.8653	1
Loa Loa (eye worm)	follicle stimulating hormone receptor	0.0097	0.8653	1
Echinococcus granulosus	g protein linked acetylcholine receptor gar 2a	0.0097	0.8653	0.7937
Loa Loa (eye worm)	G-protein coupled receptor	0.0097	0.8653	1
Echinococcus granulosus	growth hormone secretagogue receptor type 1	0.0097	0.8653	0.7937
Echinococcus multilocularis	neuropeptide s receptor	0.0097	0.8653	0.8653
Loa Loa (eye worm)	G-protein coupled receptor	0.0097	0.8653	1
Echinococcus granulosus	alpha 1A adrenergic receptor	0.0097	0.8653	0.7937
Onchocerca volvulus		0.0097	0.8653	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	serotonin receptor	0.0097	0.8653	0.8653
Brugia malayi	Dopamine receptor	0.0097	0.8653	1
Loa Loa (eye worm)	G-protein-linked acetylcholine receptor protein 2	0.0097	0.8653	1
Echinococcus multilocularis	tm gpcr rhodopsin gpcr rhodopsin superfamily	0.0097	0.8653	0.8653
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Schistosoma mansoni	opsin-like receptor	0.0097	0.8653	1
Schistosoma mansoni	neuropeptide F-like receptor	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Onchocerca volvulus		0.0097	0.8653	0.5
Schistosoma mansoni	rhodopsin-like orphan GPCR	0.0097	0.8653	1
Echinococcus multilocularis	growth hormone secretagogue receptor type 1	0.0097	0.8653	0.8653
Onchocerca volvulus	Dopamine\/Ecdysteroid receptor homolog	0.0097	0.8653	0.5
Echinococcus granulosus	rhodopsin orphan GPCR	0.0097	0.8653	0.7937
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Brugia malayi	hypothetical protein	0.0097	0.8653	1
Brugia malayi	Tachykinin-like peptides receptor 99D	0.0097	0.8653	1
Schistosoma mansoni	alpha-1 adrenergic receptor	0.0097	0.8653	1
Brugia malayi	neuropeptide F receptor	0.0097	0.8653	1
Loa Loa (eye worm)	gonadotropin-releasing hormone receptor 2	0.0097	0.8653	1
Brugia malayi	follicle stimulating hormone receptor	0.0097	0.8653	1
Echinococcus multilocularis	thyrotropin releasing hormone receptor	0.0097	0.8653	0.8653
Schistosoma mansoni	histamine h1 receptor	0.0097	0.8653	1
Onchocerca volvulus		0.0097	0.8653	0.5
Loa Loa (eye worm)	unidentified vitellogenin-linked transcript protein 6	0.0097	0.8653	1
Schistosoma mansoni	biogenic amine (5HT) receptor	0.0097	0.8653	1
Schistosoma mansoni	amine GPCR	0.0097	0.8653	1
Echinococcus granulosus	fmrfamide receptor	0.0097	0.8653	0.7937
Echinococcus multilocularis	G protein coupled receptor 139	0.0097	0.8653	0.8653
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus granulosus	pyroglutamylated rfamide peptide receptor	0.0097	0.8653	0.7937
Echinococcus granulosus	thyrotropin releasing hormone receptor	0.0097	0.8653	0.7937
Schistosoma mansoni	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	7TM GPCR, rhodopsin	0.0097	0.8653	0.8653
Echinococcus granulosus	neuropeptides capa receptor	0.0097	0.8653	0.7937
Schistosoma mansoni	peptide (FMRFamide/neurokinin-3)-like receptor	0.0097	0.8653	1
Schistosoma mansoni	neuropeptide receptor	0.0097	0.8653	1
Brugia malayi	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	pyroglutamylated rfamide peptide receptor	0.0097	0.8653	0.8653
Echinococcus granulosus	somatostatin receptor	0.0097	0.8653	0.7937
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Loa Loa (eye worm)	neuropeptide F receptor	0.0097	0.8653	1
Brugia malayi	sulfakinin receptor protein	0.0097	0.8653	1
Schistosoma mansoni	peptide (FMRFamide/somatostatin)-like receptor	0.0097	0.8653	1
Brugia malayi	G-protein coupled receptor	0.0097	0.8653	1
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	guanine nucleotide binding protein G(s) subunit	0.0055	0.3471	0.3471
Onchocerca volvulus		0.0097	0.8653	0.5
Loa Loa (eye worm)	hypothetical protein	0.0097	0.8653	1
Echinococcus multilocularis	neuropeptide receptor A26	0.0097	0.8653	0.8653

Activities

Activity type	Activity value	Assay description	Source	Reference
Potency (functional)	0.9285 uM	PUBCHEM_BIOASSAY: Primary qHTS for delayed death inhibitors of the malarial parasite plastid, 96 hour incubation. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488745, AID488752, AID488774, AID504848, AID504850]	ChEMBL.	No reference
Potency (functional)	3.5481 uM	PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory)	ChEMBL.	No reference
Potency (functional)	44.6684 uM	PubChem BioAssay. qHTS of Trypanosoma Brucei Inhibitors. (Class of assay: confirmatory)	ChEMBL.	No reference

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Plasmodium falciparum	ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL1879468
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Bibliographic References

No literature references available for this target.

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Detailed information for compound 825370