Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Probable peptidoglycan hydrolase | 0.1006 | 0.2822 | 0.5 |
Brugia malayi | Hemopexin family protein | 0.1125 | 0.3242 | 0.2479 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 0.2186 | 0.2447 |
Mycobacterium ulcerans | hydrolase | 0.1006 | 0.2822 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0907 | 0.2472 | 0.2954 |
Onchocerca volvulus | Matrix metalloproteinase homolog | 0.1832 | 0.574 | 0.9257 |
Loa Loa (eye worm) | matrixin family protein | 0.1832 | 0.574 | 0.8749 |
Brugia malayi | Matrix metalloprotease, N-terminal domain containing protein | 0.1006 | 0.2822 | 0.1493 |
Loa Loa (eye worm) | matrixin family protein | 0.2032 | 0.6446 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.1006 | 0.2822 | 0.3575 |
Loa Loa (eye worm) | hypothetical protein | 0.0826 | 0.2186 | 0.2447 |
Echinococcus multilocularis | matrix metallopeptidase 7 (M10 family) | 0.3038 | 1 | 1 |
Brugia malayi | Matrixin family protein | 0.2032 | 0.6446 | 1 |
Onchocerca volvulus | Matrilysin homolog | 0.1913 | 0.6026 | 1 |
Schistosoma mansoni | matrix metallopeptidase-7 (M10 family) | 0.0907 | 0.2472 | 0.7623 |
Schistosoma mansoni | hypothetical protein | 0.1125 | 0.3242 | 1 |
Onchocerca volvulus | 0.1125 | 0.3242 | 0.2751 | |
Mycobacterium leprae | PROBABLE HYDROLASE | 0.1006 | 0.2822 | 0.5 |
Loa Loa (eye worm) | matrix metalloproteinase | 0.0826 | 0.2186 | 0.2447 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.