Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Equus caballus | Ferritin light chain | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | expressed protein | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma japonicum | Ferritin, putative | Ferritin light chain | 175 aa | 144 aa | 24.3 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 142 aa | 29.6 % |
Schistosoma mansoni | apoferritin-2 | Ferritin light chain | 175 aa | 146 aa | 28.8 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 43.9 % |
Schistosoma mansoni | ferritin | Ferritin light chain | 175 aa | 171 aa | 44.4 % |
Echinococcus multilocularis | expressed protein | Ferritin light chain | 175 aa | 146 aa | 30.1 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | cardiolipin synthetase | 0.0917 | 0.1973 | 0.5 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0917 | 0.1973 | 0.5 |
Echinococcus granulosus | phospholipase D | 0.2322 | 0.8562 | 0.8562 |
Loa Loa (eye worm) | hypothetical protein | 0.2207 | 0.8027 | 1 |
Brugia malayi | Phospholipase D. Active site motif family protein | 0.0917 | 0.1973 | 0.1973 |
Entamoeba histolytica | phospholipase D, putative | 0.2628 | 1 | 1 |
Entamoeba histolytica | phospholipase D, putative | 0.2628 | 1 | 1 |
Schistosoma mansoni | phospholipase D | 0.2628 | 1 | 0.5 |
Trypanosoma brucei | cardiolipin synthetase, putative | 0.0917 | 0.1973 | 0.5 |
Echinococcus multilocularis | phospholipase D | 0.2322 | 0.8562 | 0.8562 |
Echinococcus granulosus | phospholipase D1 | 0.2628 | 1 | 1 |
Onchocerca volvulus | Putative phospholipase D | 0.0496 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1712 | 0.5702 | 0.7103 |
Echinococcus multilocularis | phospholipase D1 | 0.2628 | 1 | 1 |
Trypanosoma cruzi | cardiolipin synthetase, putative | 0.0917 | 0.1973 | 0.5 |
Toxoplasma gondii | phospholipase D active site domain-containing protein | 0.0917 | 0.1973 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.2207 | 0.8027 | 1 |
Leishmania major | phosphatidylglycerophosphate synthase, putative | 0.0496 | 0 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.1712 | 0.5702 | 0.7103 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (binding) | = 19.9526 um | PUBCHEM_BIOASSAY: qHTS Assay for Identification of Novel General Anesthetics. In this assay, a GABAergic mimetic model system, apoferritin and a profluorescent 1-aminoanthracene ligand (1-AMA), was used to construct a competitive binding assay for identification of novel general anesthetics (Class of assay: confirmatory) [Related pubchem assays: 2385 (Probe Development Summary for Identification of Novel General Anesthetics), 2323 (Validation apoferritin assay run on SigmaAldrich LOPAC1280 collection)] | ChEMBL. | No reference |
Potency (functional) | 28.1838 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 89.1251 uM | PUBCHEM_BIOASSAY: qHTS Assay for Inhibitors of Mammalian Selenoprotein Thioredoxin Reductase 1 (TrxR1): qHTS. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488771] | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.