Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.004 | 0 | 0.5 |
Echinococcus multilocularis | Serine:threonine protein kinase PLK4 | 0.0233 | 0.659 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2047 | 0.5 |
Giardia lamblia | Kinase, PLK | 0.01 | 0.2047 | 0.5 |
Echinococcus granulosus | Serine:threonine protein kinase PLK4 | 0.0233 | 0.659 | 1 |
Onchocerca volvulus | Serine\/threonine kinase homolog | 0.01 | 0.2047 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2047 | 0.5 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0102 | 0.2102 | 1 |
Leishmania major | protein kinase, putative,polo-like protein kinase, putative | 0.01 | 0.2047 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2047 | 0.5 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.2047 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2047 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2047 | 0.5 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2047 | 0.5 |
Entamoeba histolytica | serine/threonine protein kinase, putative | 0.01 | 0.2047 | 0.5 |
Brugia malayi | serine/threonine-protein kinase plk-2 | 0.01 | 0.2047 | 0.9738 |
Loa Loa (eye worm) | PLK/PLK1 protein kinase | 0.01 | 0.2047 | 0.9738 |
Trypanosoma cruzi | polo-like protein kinase, putative | 0.01 | 0.2047 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0102 | 0.2102 | 1 |
Trypanosoma brucei | polo-like protein kinase | 0.01 | 0.2047 | 1 |
Trichomonas vaginalis | CAMK family protein kinase | 0.01 | 0.2047 | 0.5 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.