Detailed information for compound 827732

Basic information

Technical information
  • TDR Targets ID: 827732
  • Name: N-(4-methylphenyl)-2-[(2-oxo-3,4-dihydro-1H-q uinolin-6-yl)sulfonylamino]-2-phenylacetamide
  • MW: 449.522 | Formula: C24H23N3O4S
  • H donors: 3 H acceptors: 4 LogP: 3 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCc2c(N1)ccc(c2)S(=O)(=O)NC(C(=O)Nc1ccc(cc1)C)c1ccccc1
  • InChi: 1S/C24H23N3O4S/c1-16-7-10-19(11-8-16)25-24(29)23(17-5-3-2-4-6-17)27-32(30,31)20-12-13-21-18(15-20)9-14-22(28)26-21/h2-8,10-13,15,23,27H,9,14H2,1H3,(H,25,29)(H,26,28)
  • InChiKey: SLGXTGPEOVIZJB-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-methylphenyl)-2-[(2-oxo-3,4-dihydro-1H-quinolin-6-yl)sulfonylamino]-2-phenyl-acetamide
  • 2-[(2-keto-3,4-dihydro-1H-quinolin-6-yl)sulfonylamino]-N-(4-methylphenyl)-2-phenyl-acetamide
  • N-(4-methylphenyl)-2-[(2-oxo-3,4-dihydro-1H-quinolin-6-yl)sulfonylamino]-2-phenyl-ethanamide

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi heat shock protein 90, putative 0.1131 0.2281 0.2281
Trypanosoma cruzi heat shock protein 85, putative 0.1131 0.2281 0.2281
Toxoplasma gondii heat shock protein 90, putative 0.1131 0.2281 0.9646
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Trypanosoma brucei developmentally regulated phosphoprotein 0.2522 1 1
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0798 0.0431 0.5
Entamoeba histolytica heat shock protein 90, putative 0.1131 0.2281 0.5
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.2522 1 1
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Treponema pallidum heat shock protein 90 0.0798 0.0431 0.5
Trypanosoma brucei heat shock protein, putative 0.1131 0.2281 0.1877
Echinococcus granulosus heat shock protein 0.1131 0.2281 0.1933
Trypanosoma brucei heat shock protein, putative 0.1131 0.2281 0.1877
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.2522 1 1
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Leishmania major developmentally regulated phosphoprotein-like protein 0.2522 1 1
Entamoeba histolytica heat shock protein 90, putative 0.1131 0.2281 0.5
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0798 0.0431 0.5
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0798 0.0431 0.5
Trichomonas vaginalis heat shock protein, putative 0.0798 0.0431 0.1406
Trypanosoma brucei heat shock protein, putative 0.1131 0.2281 0.1877
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Trypanosoma brucei heat shock protein, putative 0.1131 0.2281 0.1877
Schistosoma mansoni pyruvate dehydrogenase 0.2189 0.815 0.7604
Toxoplasma gondii heat shock protein HSP90 0.1131 0.2281 0.9646
Trypanosoma brucei heat shock protein, putative 0.1131 0.2281 0.1877
Trypanosoma cruzi heat shock protein 85, putative 0.1131 0.2281 0.2281
Trichomonas vaginalis heat shock protein, putative 0.1131 0.2281 1
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.081 0.0497 0.0497
Trypanosoma brucei heat shock protein, putative 0.1131 0.2281 0.1877
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.081 0.0497 0.0068
Echinococcus granulosus heat shock protein 90 0.1131 0.2281 0.1933
Schistosoma mansoni pyruvate dehydrogenase 0.2522 1 1
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Trichomonas vaginalis heat shock protein, putative 0.0798 0.0431 0.1406
Trypanosoma brucei Heat shock protein 83, putative 0.1131 0.2281 0.1877
Mycobacterium ulcerans heat shock protein 90 0.0798 0.0431 0.5
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.2522 1 1
Echinococcus multilocularis heat shock protein 90 0.1131 0.2281 0.1933
Giardia lamblia Heat shock protein HSP 90-alpha 0.1131 0.2281 1
Trypanosoma brucei heat shock protein, putative 0.1131 0.2281 0.1877
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.1143 0.2346 1
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Trypanosoma brucei heat shock protein 90, putative 0.1131 0.2281 0.1877
Plasmodium vivax endoplasmin, putative 0.1131 0.2281 0.5
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Schistosoma mansoni pyruvate dehydrogenase 0.2189 0.815 0.7604
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Trypanosoma brucei heat shock protein, putative 0.1131 0.2281 0.1877
Trypanosoma brucei heat shock protein 90, putative 0.1131 0.2281 0.1877
Plasmodium falciparum heat shock protein 90 0.1131 0.2281 1
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Trypanosoma cruzi heat shock protein 85, putative 0.0798 0.0431 0.0431
Trypanosoma cruzi Heat shock protein 83, putative 0.1131 0.2281 0.2281
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Echinococcus multilocularis heat shock protein 0.1131 0.2281 0.1933
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.2522 1 1
Trypanosoma cruzi heat shock protein 90, putative 0.0798 0.0431 0.0431
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Loa Loa (eye worm) hypothetical protein 0.2522 1 1
Trichomonas vaginalis heat shock protein, putative 0.0798 0.0431 0.1406
Leishmania major heat shock protein 83-1 0.1131 0.2281 0.1933
Trypanosoma cruzi heat shock protein 85, putative 0.1131 0.2281 0.2281
Plasmodium vivax heat shock protein 86, putative 0.1131 0.2281 0.5

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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