Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | c4b-binding protein beta chain | 0.0113 | 0.0983 | 0.2382 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0147 | 0.1561 | 0.764 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0161 | 0.1798 | 0.0904 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0234 | 0.3041 | 1 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0147 | 0.1561 | 0.7094 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0147 | 0.1561 | 0.3433 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0147 | 0.1561 | 0.0641 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1798 | 0.3954 |
Echinococcus granulosus | laminin | 0.0161 | 0.1798 | 0.5026 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0305 | 0.4264 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0161 | 0.1798 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.2605 | 0.5727 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0178 | 0.039 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0234 | 0.3041 | 1 |
Echinococcus multilocularis | laminin | 0.0161 | 0.1798 | 0.5026 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0161 | 0.1798 | 1 |
Brugia malayi | Fibulin-1 precursor | 0.0161 | 0.1798 | 1 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0147 | 0.1561 | 0.3566 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0313 | 0.4402 | 0.3791 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0161 | 0.1798 | 0.0904 |
Giardia lamblia | DNA topoisomerase II | 0.0136 | 0.1376 | 0.5 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0147 | 0.1561 | 0.764 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0147 | 0.1561 | 0.0641 |
Brugia malayi | Trypsin family protein | 0.0139 | 0.1425 | 0.5417 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1798 | 0.3954 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0313 | 0.4402 | 0.43 |
Brugia malayi | Probable DNA topoisomerase II | 0.0147 | 0.1561 | 0.7094 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0208 | 0.2605 | 1 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0147 | 0.1561 | 0.7094 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0147 | 0.1561 | 0.3566 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0234 | 0.3041 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0186 | 0.2231 | 0.8245 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.4549 | 1 |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.064 | 1 | 1 |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.064 | 1 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1425 | 0.3132 |
Schistosoma mansoni | egf-like domain protein | 0.0161 | 0.1798 | 0.6211 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0147 | 0.1561 | 0.5 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0161 | 0.1798 | 0.3954 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0313 | 0.4402 | 0.3791 |
Echinococcus granulosus | Tolloid protein 1 | 0.0208 | 0.2605 | 1 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0234 | 0.3041 | 1 |
Onchocerca volvulus | Arrow homolog | 0.0161 | 0.1798 | 1 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0208 | 0.2605 | 0.5727 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Plasmodium falciparum | DNA gyrase subunit A | 0.064 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1425 | 0.3132 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.064 | 1 | 1 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0167 | 0.1902 | 0.102 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.064 | 1 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0139 | 0.1425 | 0.4456 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0178 | 0.039 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0161 | 0.1798 | 0.3954 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1798 | 0.3954 |
Onchocerca volvulus | 0.0139 | 0.1425 | 0.6277 | |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0113 | 0.0983 | 0.2162 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.064 | 1 | 1 |
Echinococcus multilocularis | fibrillin 1 | 0.0161 | 0.1798 | 0.5026 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Schistosoma mansoni | DNA topoisomerase II | 0.0147 | 0.1561 | 0.5099 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0147 | 0.1561 | 0.764 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0227 | 0.2922 | 0.2795 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0147 | 0.1561 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0147 | 0.1561 | 0.0641 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0208 | 0.2605 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.