Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Giardia lamblia | DNA topoisomerase II | 0.0136 | 0.1376 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1798 | 0.3954 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Toxoplasma gondii | ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein | 0.0167 | 0.1902 | 0.102 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0139 | 0.1425 | 0.4456 |
Echinococcus multilocularis | DNA topoisomerase 2 alpha | 0.0147 | 0.1561 | 0.3566 |
Onchocerca volvulus | Arrow homolog | 0.0161 | 0.1798 | 1 |
Schistosoma mansoni | subfamily S1A unassigned peptidase (S01 family) | 0.0186 | 0.2231 | 0.8245 |
Schistosoma mansoni | DNA topoisomerase II | 0.0147 | 0.1561 | 0.5099 |
Trypanosoma brucei | DNA topoisomerase ii | 0.0234 | 0.3041 | 1 |
Leishmania major | mitochondrial DNA topoisomerase II | 0.0234 | 0.3041 | 1 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0161 | 0.1798 | 0.0904 |
Brugia malayi | Calcium binding EGF domain containing protein | 0.0161 | 0.1798 | 1 |
Schistosoma mansoni | c4b-binding protein beta chain | 0.0113 | 0.0983 | 0.2382 |
Mycobacterium leprae | Probable DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (Type II DNA topoisomerase) | 0.0305 | 0.4264 | 1 |
Trichomonas vaginalis | DNA topoisomerase II, putative | 0.0147 | 0.1561 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0234 | 0.3041 | 1 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0147 | 0.1561 | 0.764 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Mycobacterium tuberculosis | DNA gyrase (subunit A) GyrA (DNA topoisomerase (ATP-hydrolysing)) (DNA topoisomerase II) (type II DNA topoisomerase) | 0.064 | 1 | 1 |
Toxoplasma gondii | DNA gyrase/topoisomerase IV, A subunit domain-containing protein | 0.064 | 1 | 1 |
Trypanosoma cruzi | mitochondrial DNA topoisomerase II, putative | 0.0234 | 0.3041 | 1 |
Plasmodium vivax | DNA topoisomerase II, putative | 0.0147 | 0.1561 | 0.0641 |
Toxoplasma gondii | calcium binding egf domain-containing protein | 0.0161 | 0.1798 | 0.0904 |
Loa Loa (eye worm) | hypothetical protein | 0.0322 | 0.4549 | 1 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Echinococcus multilocularis | fibrillin 1 | 0.0161 | 0.1798 | 0.5026 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Mycobacterium ulcerans | DNA gyrase subunit A | 0.064 | 1 | 1 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Echinococcus granulosus | Tolloid protein 1 | 0.0208 | 0.2605 | 1 |
Plasmodium vivax | DNA gyrase subunit A, putative | 0.064 | 1 | 1 |
Echinococcus granulosus | laminin | 0.0161 | 0.1798 | 0.5026 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Plasmodium falciparum | DNA gyrase subunit A | 0.064 | 1 | 1 |
Loa Loa (eye worm) | pregnancy-associated plasma protein-E | 0.0113 | 0.0983 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0178 | 0.039 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Brugia malayi | Low-density lipoprotein receptor repeat class B containing protein | 0.0161 | 0.1798 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Echinococcus multilocularis | laminin | 0.0161 | 0.1798 | 0.5026 |
Brugia malayi | DNA topoisomerase II, alpha isozyme | 0.0147 | 0.1561 | 0.7094 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0313 | 0.4402 | 0.43 |
Brugia malayi | Trypsin family protein | 0.0139 | 0.1425 | 0.5417 |
Brugia malayi | DNA gyrase/topoisomerase IV, A subunit family protein | 0.0147 | 0.1561 | 0.7094 |
Loa Loa (eye worm) | hypothetical protein | 0.0066 | 0.0178 | 0.039 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Onchocerca volvulus | 0.0139 | 0.1425 | 0.6277 | |
Brugia malayi | Fibulin-1 precursor | 0.0161 | 0.1798 | 1 |
Entamoeba histolytica | DNA topoisomerase II, putative | 0.0147 | 0.1561 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1425 | 0.3132 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1798 | 0.3954 |
Loa Loa (eye worm) | low-density lipoprotein receptor repeat class B containing protein | 0.0161 | 0.1798 | 0.3954 |
Plasmodium falciparum | DNA gyrase subunit B | 0.0313 | 0.4402 | 0.3791 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Plasmodium vivax | DNA gyrase subunit B, putative | 0.0313 | 0.4402 | 0.3791 |
Toxoplasma gondii | DNA topoisomerase 2, putative | 0.0147 | 0.1561 | 0.0641 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.1798 | 0.3954 |
Echinococcus granulosus | DNA topoisomerase 2 alpha | 0.0147 | 0.1561 | 0.3566 |
Wolbachia endosymbiont of Brugia malayi | DNA gyrase subunit A | 0.064 | 1 | 1 |
Brugia malayi | Probable DNA topoisomerase II | 0.0147 | 0.1561 | 0.7094 |
Chlamydia trachomatis | DNA gyrase subunit B | 0.0227 | 0.2922 | 0.2795 |
Schistosoma mansoni | subfamily M12A unassigned peptidase (M12 family) | 0.0208 | 0.2605 | 1 |
Loa Loa (eye worm) | multiple epidermal growth factor-like domains 6 | 0.0161 | 0.1798 | 0.3954 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Loa Loa (eye worm) | bone morphogenetic protein 1b | 0.0208 | 0.2605 | 0.5727 |
Plasmodium falciparum | DNA topoisomerase 2 | 0.0147 | 0.1561 | 0.0641 |
Schistosoma mansoni | egf-like domain protein | 0.0161 | 0.1798 | 0.6211 |
Loa Loa (eye worm) | hypothetical protein | 0.0208 | 0.2605 | 0.5727 |
Echinococcus multilocularis | Tolloid protein 1 | 0.0208 | 0.2605 | 1 |
Loa Loa (eye worm) | TOPoisomerase family member | 0.0147 | 0.1561 | 0.3433 |
Loa Loa (eye worm) | hypothetical protein | 0.0139 | 0.1425 | 0.3132 |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Onchocerca volvulus | DNA topoisomerase 2 homolog | 0.0147 | 0.1561 | 0.764 |
Onchocerca volvulus | Putative DNA topoisomerase 2, mitochondrial | 0.0147 | 0.1561 | 0.764 |
Onchocerca volvulus | 0.0113 | 0.0983 | 0.1878 | |
Loa Loa (eye worm) | hypothetical protein | 0.0113 | 0.0983 | 0.2162 |
Treponema pallidum | DNA gyrase, subunit A (gyrA) | 0.064 | 1 | 1 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.